Mouse anti NKR-P1-A antibodyB antibodyC

  • Catalog number
    X1166M
  • Price
    Please ask
  • Size
    100 μg
  • Category
    Primary Antibodies
  • Long description
    Natural Killer (NK) cells are large, granular lymphocytes found primarily in peripheral blood, where they make up about 10% of the lymphocyte population. Their function is to defend against certain types of tumor cells and virally infected cells. When triggered, the cells release cytotoxic granules which induce either apoptosis or necrosis in the target cell. There are known to be two sets of cell surface receptor on NK cells which recognize target cells with opposing functions. One set, of which an example is NKR-P1 receptors, trigger cytokine release and cell cytotoxicity and the other set, of which Ly49A is an example, inhibit cytokine release. These receptors bind with MHC class I molecules on the surface of healthy cells which inhibits the release of cytokines. In virally infected or cancerous cells, class I MHC molecules are not expressed, inducing the release of cytokine. An activation signal is known to exist, however the mechanics of this signal are not very well understood.
  • Antibody come from
    Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized (BALB/c X C57BL/6)F1 (CbyB6F1) lymphokine-activated killer (LAK) cells and mouse myeloma cell line.
  • Other description
    Provided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
  • Clone
    1C10
  • Antigen antibody binding interaction
    Mouse anti NKR-P1-A antibodyB antibodyC Antibody
  • Antibody is raised in
    Mouse
  • Antibody s reacts with
    Mouse
  • Antibody s reacts with these species
    This antibody doesn't cross react with other species
  • Antibody s specificity
    No Data Available
  • Application
    Immunoprecipitation, Western Blot, Flow Cytometry
  • Antibody s suited for
    Recommended starting concentration for Western blot is 1-5 µg/ml. Binds to NKR-P1 receptors and induces release of cytokine in SJL/J NK cells.1 Optimal concentration should be evaluated by serial dilutions.
  • Storage
    -20ºC
  • Relevant references
    1. Kung, S.K.P., et al. 'The NKR-P1B gene product is an inhibitory receptor on SJL/J NK cells.' J. Immunol. 1999, 162, 5876-5887_x000B__x000B_2. Gardiner, C.M. 'Natural killer cells.' Curr. Biol. 1999, 9, R716
  • Protein number
    see ncbi
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Test
    Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
  • Latin name
    Mus musculus
  • Gene target
  • Gene symbol
    KLRB1, CRYGFP, TACR3, SH3GL1P1, HLA-A, COLEC12, KRTAP5-13P, PRF1, IGHV5-10-1, CIDEA
  • Short name
    Mouse anti NKR-P1-A antibodyB antibodyC
  • Technique
    Mouse, anti, antibody to, mouses
  • Host
    mouse
  • Isotype
    IgG
  • Label
    unlabeled
  • Species
    Mouse, Mouses
  • Alternative name
    Mouse antibody to NKR-P1-A antibodyB antibodyC
  • Alternative technique
    murine, antibodies
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    crystallin gamma F, pseudogene
  • Synonyms gene
  • Synonyms gene name
    • crystallin, gamma F pseudogene 1
    • crystallin, gamma F pseudogene
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1986-01-01
  • Entrez gene record
  • Classification
    • Beta-gamma crystallins
  • VEGA ID
Gene info
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    keratin associated protein 5-13, pseudogene
  • Synonyms gene
  • Synonyms gene name
    • keratin associated protein 5 pseudogene 1
  • Synonyms
  • Locus
  • Discovery year
    2003-12-01
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Keratin associated proteins
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin heavy variable 5-10-1
  • Synonyms gene
  • Synonyms gene name
    • immunoglobulin heavy variable 5-A (provisional, gene/pseudogene)
    • immunoglobulin heavy variable 5-A (provisional)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-04
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin heavy locus at 14q32.33
  • VEGA ID
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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