Mouse anti NKR-P1-A antibodyB antibodyC
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Catalog numberX1166M
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PricePlease ask
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Size100 μg
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CategoryPrimary Antibodies
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Long descriptionNatural Killer (NK) cells are large, granular lymphocytes found primarily in peripheral blood, where they make up about 10% of the lymphocyte population. Their function is to defend against certain types of tumor cells and virally infected cells. When triggered, the cells release cytotoxic granules which induce either apoptosis or necrosis in the target cell. There are known to be two sets of cell surface receptor on NK cells which recognize target cells with opposing functions. One set, of which an example is NKR-P1 receptors, trigger cytokine release and cell cytotoxicity and the other set, of which Ly49A is an example, inhibit cytokine release. These receptors bind with MHC class I molecules on the surface of healthy cells which inhibits the release of cytokines. In virally infected or cancerous cells, class I MHC molecules are not expressed, inducing the release of cytokine. An activation signal is known to exist, however the mechanics of this signal are not very well understood.
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Antibody come fromHybridoma produced by the fusion of splenocytes from BALB/c mice immunized (BALB/c X C57BL/6)F1 (CbyB6F1) lymphokine-activated killer (LAK) cells and mouse myeloma cell line.
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Other descriptionProvided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
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Clone1C10
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Antigen antibody binding interactionMouse anti NKR-P1-A antibodyB antibodyC Antibody
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Antibody is raised inMouse
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Antibody s reacts withMouse
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Antibody s reacts with these speciesThis antibody doesn't cross react with other species
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Antibody s specificityNo Data Available
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ApplicationImmunoprecipitation, Western Blot, Flow Cytometry
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Antibody s suited forRecommended starting concentration for Western blot is 1-5 µg/ml. Binds to NKR-P1 receptors and induces release of cytokine in SJL/J NK cells.1 Optimal concentration should be evaluated by serial dilutions.
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Storage-20ºC
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Relevant references1. Kung, S.K.P., et al. 'The NKR-P1B gene product is an inhibitory receptor on SJL/J NK cells.' J. Immunol. 1999, 162, 5876-5887_x000B__x000B_2. Gardiner, C.M. 'Natural killer cells.' Curr. Biol. 1999, 9, R716
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Protein numbersee ncbi
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WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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Gene target
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Gene symbolKLRB1, CRYGFP, TACR3, SH3GL1P1, HLA-A, COLEC12, KRTAP5-13P, PRF1, IGHV5-10-1, CIDEA
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Short nameMouse anti NKR-P1-A antibodyB antibodyC
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TechniqueMouse, anti, antibody to, mouses
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Hostmouse
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IsotypeIgG
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Labelunlabeled
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SpeciesMouse, Mouses
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Alternative nameMouse antibody to NKR-P1-A antibodyB antibodyC
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Alternative techniquemurine, antibodies
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Gene info
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Identity
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Gene
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Long gene namekiller cell lectin like receptor B1
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Synonyms gene
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Synonyms gene name
- killer cell lectin-like receptor subfamily B, member 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-01-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Killer cell lectin like receptors
- C-type lectin domain containing
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecrystallin gamma F, pseudogene
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Synonyms gene
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Synonyms gene name
- crystallin, gamma F pseudogene 1
- crystallin, gamma F pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Classification
- Beta-gamma crystallins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametachykinin receptor 3
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-11-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tachykinin receptors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameSH3 domain containing GRB2 like 1, endophilin A2 pseudogene 1
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Synonyms gene
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Synonyms gene name
- SH3-domain GRB2-like pseudogene 1
- SH3 domain containing GRB2 like 1 pseudogene 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1996-10-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class I, A
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namecollectin subfamily member 12
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-12-13
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Entrez gene record
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Pubmed identfication
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Classification
- Scavenger receptors
- Collectins
- C-type lectin domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namekeratin associated protein 5-13, pseudogene
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Synonyms gene
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Synonyms gene name
- keratin associated protein 5 pseudogene 1
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Synonyms
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Locus
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Discovery year2003-12-01
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Entrez gene record
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Pubmed identfication
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Classification
- Keratin associated proteins
Gene info
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Identity
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Gene
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Long gene nameperforin 1
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Synonyms gene name
- perforin 1 (pore forming protein)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1989-02-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C2 domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 5-10-1
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Synonyms gene
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Synonyms gene name
- immunoglobulin heavy variable 5-A (provisional, gene/pseudogene)
- immunoglobulin heavy variable 5-A (provisional)
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-04
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecell death inducing DFFA like effector a
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Synonyms gene name
- cell death-inducing DFFA-like effector a
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-07-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data