Rabbit Anti Human CACNA1C Antibody-Biotin

• Catalog number
  CSB-PA615724LD01HU_50ug
• Price
  Please ask
• Size
  50ug

• Long name
  Rabbit Antibody against Human CACNA1C, Biotin
• Synonym name
  CACNA1C Human Antibody
• Species reactivity
  Human
• Tested applications recommended dilutions
  ELISA
• Conjugation
  Biotin
• Antibody isotype
  IgG
• UniProt ID
  Q13936
• Format
  Liquid, diluted in buffer
• Buffer composition
  Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Purity
  >95%
• Purification method
  Protein G purified
• Antibody category
  Polyclonal Antibodies
• Immunogen type
  Recombinant Human Voltage-dependent L-type calcium channel subunit alpha-1C protein (1755-1971AA)
• Immunogen species
  Human
• Alias
  Voltage-dependent L-type calcium channel subunit alpha-1C,Calcium channel,L type,alpha-1 polypeptide,isoform 1,cardiac muscle,Voltage-gated calcium channel subunit alpha Cav1.2,CACNA1C,CACH2,CACN2,CACNL1A1,CCHL1A1
• Background
  Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.
• Clonality
  Polyclonal antibody
• Shipping and storage
  CACNA1C Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
• Short name of the antigen
  Voltage-dependent L-type calcium channel subunit alpha-1C
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
• Properties
  If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional conjugation
  Biotinylated
• About
  Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus
• French translation
  anticorps

• Gene target
  CACNA1C  
• Gene symbol
  CACNA1C-AS1, CACNA1C-IT1, CACNA1C-AS4, CACNA1C-IT2, CACNA1C-AS3, CACNA1C-AS2, CACNA1C-IT3, CACNA1C
• Short name
  Anti-CACNA1C
• Technique
  anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
• Host
  Rabbit, Rabbits
• Label
  Biotin
• Species
  Human, Humans
• Alternative name
  CACNA1C Antibody,Biotin conjugated
• Alternative technique
  antibodies, rabbit-anti

Gene info

• Identity
  HGNC:40119
• Gene
  CACNA1C-AS1
• Long gene name
  CACNA1C antisense RNA 1
• Synonyms gene name
  • CACNA1C antisense RNA 1 (non-protein coding)
• Locus
  12p13.33
• Discovery year
  2011-05-31
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000168139

Gene info

• Identity
  HGNC:41312
• Gene
  CACNA1C-IT1
• Long gene name
  CACNA1C intronic transcript 1
• Synonyms gene name
  • CACNA1C intronic transcript 1 (non-protein coding)
• Locus
  12p13.33
• Discovery year
  2011-05-31
• Classification
  • Intronic transcripts
• VEGA ID
  OTTHUMG00000168337

Gene info

• Identity
  HGNC:40116
• Gene
  CACNA1C-AS4
• Long gene name
  CACNA1C antisense RNA 4
• Synonyms gene name
  • CACNA1C antisense RNA 4 (non-protein coding)
• Locus
  12p13.33
• Discovery year
  2011-05-31
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000168136

Gene info

• Identity
  HGNC:41313
• Gene
  CACNA1C-IT2
• Long gene name
  CACNA1C intronic transcript 2
• Synonyms gene name
  • CACNA1C intronic transcript 2 (non-protein coding)
• Locus
  12p13.33
• Discovery year
  2011-05-31
• Classification
  • Intronic transcripts
• VEGA ID
  OTTHUMG00000168338

Gene info

• Identity
  HGNC:40117
• Gene
  CACNA1C-AS3
• Long gene name
  CACNA1C antisense RNA 3
• Synonyms gene name
  • CACNA1C antisense RNA 3 (non-protein coding)
• Locus
  12p13.33
• Discovery year
  2011-05-31
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000168137

Gene info

• Identity
  HGNC:40118
• Gene
  CACNA1C-AS2
• Long gene name
  CACNA1C antisense RNA 2
• Synonyms gene name
  • CACNA1C antisense RNA 2 (non-protein coding)
• Locus
  12p13.33
• Discovery year
  2011-05-31
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000168138

Gene info

• Identity
  HGNC:41314
• Gene
  CACNA1C-IT3
• Long gene name
  CACNA1C intronic transcript 3
• Synonyms gene name
  • CACNA1C intronic transcript 3 (non-protein coding)
• Locus
  12p13.33
• Discovery year
  2011-05-31
• Classification
  • Intronic transcripts
• VEGA ID
  OTTHUMG00000168201

Gene info

• Identity
  HGNC:1390
• Gene
  CACNA1C
• Long gene name
  calcium voltage-gated channel subunit alpha1 C
• Synonyms gene
  • CCHL1A1
  • CACNL1A1
• Synonyms gene name
  • calcium channel, voltage-dependent, L type, alpha 1C subunit
• Synonyms
  • Cav1.2
  • CACH2
  • CACN2
  • TS
  • LQT8
• GenBank acession
  • AF070589
• Locus
  12p13.33
• Discovery year
  1991-01-30
• Entrez gene record
  775
• Pubmed identfication
  • 1650913
  • 16382099
• RefSeq identity
  • NM_000719
• Classification
  • Calcium voltage-gated channel alpha1 subunits
• VEGA ID
  OTTHUMG00000150243
• Locus Specific Databases
  • Gene Connection for the Heart
  • CACNA1C database at LOVD-China
  • LRG_334

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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