Human CellExp™ DPPIV/CD26, human recombinant (untagged)

• Catalog number
  7436-10
• Price
  Please ask
• Size
  10 ug

• Synonyms
  DPP4, DPP-4, ADABP, ADCP2, ADCP-2, CD26, CD-26, DPPIV, DPPIV, TP103, TP-103
• Alternative_names
  DPP4, DPP-4, ADABP, ADCP2, ADCP-2, CD26, CD-26, DPPIV, DPPIV, TP103, TP-103
• Description
  An antigenic enzyme associated with immune regulation, signal transduction and apoptosis.
• Recombinant
  Yes
• Source
  HEK293 cells
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Biological activity
  Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Pro-7-amido-4-methylcoumarin (GP-AMC). The specific activity is > 5500 pmoles /min /ug.
• Results
  Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Pro-7-amido-4-methylcoumarin (GP-AMC). The specific activity is > 5500 pmoles /min /ug.
• Molecular Weight
  This protein with two amino acids (Gly-Pro) at the N- terminus has a calculated MW of 85.4 kDa expressed. Protein migrates as 95 kDa in reduced SDS-PAGE resulting from glycosylation.
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
• Reconstitution Instructions
  Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
• Background Information
  Dipeptidyl peptidase-IV (DPPIV), also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others. DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   DPPIV/CD26   untagged  
• Gene symbol
  DPP4, FAP
• Short name
  CellExp™ DPPIV/CD26, recombinant (untagged)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Humans
• Alternative name
  H. sapiens CellExp™ DPPIV/CD26, H. sapiens Rec. (untagged)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:3009
• Gene
  DPP4
• Long gene name
  dipeptidyl peptidase 4
• Synonyms gene
  • CD26
  • ADCP2
• Synonyms gene name
  • dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
  • adenosine deaminase complexing protein 2
  • dipeptidyl-peptidase 4
• Synonyms
  • DPPIV
• GenBank acession
  • M74777
• Locus
  2q24.2
• Discovery year
  1990-03-05
• Entrez gene record
  1803
• Pubmed identfication
  • 8101391
• Classification
  • CD molecules
  • DASH family
• VEGA ID
  OTTHUMG00000132056

Gene info

• Identity
  HGNC:3590
• Gene
  FAP
• Long gene name
  fibroblast activation protein alpha
• Synonyms gene name
  • fibroblast activation protein, alpha
• Synonyms
  • DPPIV
• Synonyms name
  • seprase
• GenBank acession
  • U09278
• Locus
  2q24.2
• Discovery year
  1995-03-28
• Entrez gene record
  2191
• Pubmed identfication
  • 9247085
  • 14707457
• Classification
  • DASH family
• VEGA ID
  OTTHUMG00000153890

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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