Recombinant Human PDCD4/H731 Protein(C-6His) 50µg
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Catalog number
PKSH032866-50µg
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Price
Please ask
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Size
50µg
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Synonym
Programmed Cell Death Protein 4; Neoplastic Transformation Inhibitor Protein; Nuclear Antigen H731-Like; Protein 197/15a; PDCD4; H731
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Activity
NA
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Sequence
Lys212-Pro357
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Fusion tag
C-6His
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Accession
Q53EL6
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Expressed Host
E.coli
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Shipping
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
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Purity
＞95% as determined by reducing SDS-PAGE.
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Endotoxin
＜1.0 EU per µg as determined by LAL test.
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Stability and Storage
Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
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Mol Mass
17.0 kDa
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AP Mol Mass
17 kDa
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Formulation
Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
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Reconstitution
Please refer to it for detailed information.
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Background
Programmed Cell Death Protein 4 (PDCD4) is a member of the PDCD4 family. PDCD4 and EIF4A1 form a heterotrimer. One molecule of PDCD4 binds two molecules of EIF4A1. PDCD4 takes part in apoptosis via inhibiting translation initiation and cap-dependent translation.PDCD4 promotes colonic neoplastic transformation and tumor invasion. PDCD4 is an important target for microrna R-21 in breast cancer cells. Shortage of PDCD4 expression is associated with colorectal cancer. Overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
PDCD4, PDCD4-AS1
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Short name
Recombinant PDCD4/H731 Protein(C-6His) 50µg
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Human, Humans
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Alternative name
Rec. H. sapiens programmed cellular death 4 (neoplastic transformation inhibitor)/H731 Protein(C-6His) 50µg
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Alternative technique
rec
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Alternative to gene target
programmed cell death 4 (neoplastic transformation inhibitor), PDCD4 and IDBG-89535 and ENSG00000150593 and 100616113,27250, protein binding, nuclei, Pdcd4 and IDBG-176913 and ENSMUSG00000024975 and 18569, PDCD4 and IDBG-639738 and ENSBTAG00000019434 and 506724
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Gene info
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Identity
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Gene
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Long gene name
programmed cell death 4
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Synonyms gene name
- programmed cell death 4 (neoplastic transformation inhibitor)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2000-05-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
PDCD4 antisense RNA 1
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Locus
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Discovery year
2013-03-11
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Entrez gene record
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RefSeq identity
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Classification
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
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Tree numbers
- E01.370.225.500.195.107.595.500.150
- E01.370.225.625.107.595.500.150
- E05.200.500.195.107.595.500.150
- E05.200.625.107.595.500.150
- E05.242.195.107.595.500.150
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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