Conjugated Primary Antibodies
Rabbit (Oryctolagus cuniculus)
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human COPS6
This is a highly specific antibody against COPS6.
JAB1 containing signalosome subunit 6;COP9 subunit 6 MOV34 homolog, 34 kD;MOV34 homolog, 34 kD;COP9 constitutive photomorphogenic, subunit 6; COP9 complex S6;COP9 signalosome complex subunit 6;COP9 signalosome subunit 6;cops6;CSN6;CSN6_HUMAN;hVIP;JAB1-containing signalosome subunit 6;MOV34 homolog;MOV34-34KD;Sgn3;SGN6;Signalosome subunit 6;VIP/MOV34;Vpr interacting protein;Vpr-interacting protein.
Purified by Protein A.
Human, Mouse, Rat
Gene ID Number
Background of the antigen
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.
1ug per 1ul
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Cross-reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.