Maspin, human recombinant

• Catalog number
  P1021-25
• Price
  Please ask
• Size
  25 µg

• Synonyms
  Serpin B5, PI-5
• Alternative_names
  Serpin B5, PI-5
• Description
  Tumor suppressor, blocks the growth, invasion, and metastatic properties of mammary tumors.
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  > 95%
• Assay
  SDS-PAGE
• Purity
  > 95%
• Endotoxin Level
  < 0.2 EU/ug
• Molecular Weight
  42.1 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized after extensive dialysis against PBS.
• Reconstitution Instructions
  Reconstituted in ddH2O at 100 ug/mL.
• Background Information
  Maspin is a non-inhibitory member of the serpin superfamily, a group of 40-60 kDa serine protease inhibitors. Maspin was discovered in 1994 and has been identified in prostate, thymus, testis, intestine, tongue, and lung. Recently Maspin received a great deal of attention due to its potential apoptotic role in cancers. Maspin expression predicts a better prognosis for several types of carcinomas including breast, prostate, colon, and oral squamus cell carcinoma. The level of Maspin is also inversely correlated to VEGF-A, an angiogenic factor. Researchers found that Maspin may play its apoptotic role as an endogenous inhibitor of histone deacetylase I (HDAC I). Therefore, Maspin is a potential personalized marker of Non-Small Cell Lung Carcinoma (NSCLC).
• Amino acid sequence
  MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF ENVKDIPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDLT DGHFENILAD NSVNDQTKIL VVNAAYFVGK WMKKFPESET KECPFRLNKT DTKPVQMMNM EATFCMGNID SINCKIIELP FQNKHLSMFI LLPKDVEDES TGLEKIEKQL NSESLSQWTN PSTMANAKVK LSIPKFKVEK MIDPKACLEN LGLKHIFSED TSDFSGMSET KGVALSNVIH KVCLEITEDG GDSIEVPGAR ILQHKDELNA DHPFIYIIRH NKTRNIIFFG KFCSP
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Maspin  
• Gene symbol
  SERPINB5
• Short name
  Maspin, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Maspin, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:8949
• Gene
  SERPINB5
• Long gene name
  serpin family B member 5
• Synonyms gene
  • PI5
• Synonyms gene name
  • serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
  • serpin peptidase inhibitor, clade B (ovalbumin), member 5
• Synonyms
  • maspin
• Synonyms name
  • protease inhibitor 5 (maspin)
• GenBank acession
  • U04313
• Locus
  18q21.33
• Discovery year
  1994-06-20
• Entrez gene record
  5268
• Pubmed identfication
  • 8290962
  • 7724531
  • 16720730
  • 24172014
• RefSeq identity
  • NM_002639
• Classification
  • Serpin peptidase inhibitors
• VEGA ID
  OTTHUMG00000141307

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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