PKI-402
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Catalog numberB1727-5
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PricePlease ask
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Size5 mg
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Alternative_namePKI-402; PKI402; PKI 402; 1-[4-(3-ethyl-7-morpholin-4-yltriazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-[4-(4-methylpiperazine-1-carbonyl)phenyl]urea; 3-{4-[3-ethyl-7-(morpholin-4-yl)-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]phenyl}-1-[4-(4-methylpiperazine-1-carbonyl)phenyl]urea
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DescriptionPKI-402 is a potent dual inhibitor of PI3K/mTOR with IC50 values of 2 nM/7 nM/16 nM/14 nM and 3 nM for PI3Kα/β/γ/δ and mTOR, respectively.
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CAS Number1173204-81-3
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₉H₃₄N₁₀O₃
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Molecular Weight570.65
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Cell PermeableYes
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Purity>98%
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineA potent dual inhibitor of PI3K/mTOR
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD18251484
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PubChem CID44187953
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SMILESCCN1C2=C(C(=NC(=N2)C3=CC=C(C=C3)NC(=O)NC4=CC=C(C=C4)C(=O)N5CCN(CC5)C)N6CCOCC6)N=N1
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InChiInChI=1S/C29H34N10O3/c1-3-39-27-24(34-35-39)26(37-16-18-42-19-17-37)32-25(33-27)20-4-8-22(9-5-20)30-29(41)31-23-10-6-21(7-11-23)28(40)38-14-12-36(2)13-15-38/h4-11H,3,12-19H2,1-2H3,(H2,30,31,41)
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InChi KeyZAXFYGBKZSQBIV-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short namePKI-402
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Alternative namePKI-402
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