AGI-6780

• Catalog number
  9624-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulfonamide
• Description
  AGI-6780 is a potent, selective inhibitor of mutant Isocitrate dehydrogenase 2 (IDH2) (IC₅₀ = 23 nM). It binds allosterically at the dimer interface of mutant IDH2-R140Q, inhibiting 2-hydroxyglutarate (2-HG) formation in human glioblastoma U87 and TF-1 cells expressing IDH2-R140Q with IC₅₀ values of 11 and 18 nM, respectively.
• CAS Number
  1432660-47-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₁₈F₃N₃O₃S₂
• Molecular Weight
  481.51
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~30 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent, selective inhibitor of mutant Isocitrate dehydrogenase 2 (IDH2).
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  71299339
• PubChem CID Link
• SMILES
  C1CC1NS(=O)(=O)C2=CC(=C(C=C2)C3=CSC=C3)NC(=O)NC4=CC=CC(=C4)C(F)(F)F
• InChi
  InChI=1S/C21H18F3N3O3S2/c22-21(23,24)14-2-1-3-16(10-14)25-20(28)26-19-11-17(32(29,30)27-15-4-5-15)6-7-18(19)13-8-9-31-12-13/h1-3,6-12,15,27H,4-5H2,(H2,25,26,28)
• InChi Key
  CCAWRGNYALGPQH-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  AGI-6780  
• Short name
  AGI-6780
• Alternative name
  AGI-6780

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