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Spautin 1 Autophagy inhibitor

Spautin 1 Autophagy inhibitor is available 2 times from Stressma labs

SIH-404-5MG | Spautin-1, Autophagy inhibitor size: 5 mg | 171.38 USD

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SIH-404-25MG | Spautin-1, Autophagy inhibitor size: 25 mg | 518.85 USD

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Stock availabilitIn Stock In Stock
CAS number 1262888-28-7
Description Autophagy inhibitor
Molecular weight 271,26 g/mol
Primary research fields Cancer, Autophagy
Other name 6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine
Product category Small Molecules
Product type Inhibitor
Chemical formula C15H11F2N3
Origin Synthetic
Purity pourcentage ≥98%
Soluble in Soluble in DMSO (15 mg/ml).
Physical appearance White to beige powder.
Storage recommendations -20ºC
Shipping recommendations Shipped Ambient
Safety information Classification: D2B- Toxic Material Causing Other Toxic Effects, Severe eye irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H318- Causes serious eye damage. Precautionary statements: P280- Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
PubChem number 51037431
Scientific context Spautin-1 inhibits the deubiquitination activity of USP10 and USP13, two ubiquitin-specific peptidases. This results in the degradation of class III PI3 kinase complexes. Because this group of kinases regulates autophagy, Spautin-1 in turn inhibits autophagy.
Bibliography 1. Liu J., et al. (2011) Cell. 147(1): 223-34.
Release date 31-Mar-2014
PubMed number Refer to PubMed
Tested applications To be tested
Tested reactivity To be tested
Representative figure legend Chemical structure of Spautin-1 (SIH-404), a Autophagy inhibitor. CAS #: 1262888-28-7. Molecular Formula: C15H11F2N3. Molecular Weight: 271.26 g/mol. Chemical structure of Spautin-1, a Autophagy inhibitor (SIH-404). CAS # 1262888-28-7. Molecular Formula: C15H11F2N3.
Warning information Non-hazardous
Country of production Canada
Total weight (kg) 0.25
Additional description Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
Gene targetSpautin-1 Autophagy inhibitor
Short name Spautin-1, Autophagy inhibitor
Alternative name Spautin-1, Autophagy suppressor
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