Spautin-1, Autophagy inhibitor

• Catalog number
  SIH-404-5MG
• Price
  Please ask
• Size
  5 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  1262888-28-7
• Description
  Autophagy inhibitor
• Molecular weight
  271,26 g/mol
• Primary research fields
  Cancer, Autophagy
• Other name
  6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C15H11F2N3
• Origin
  Synthetic
• Purity pourcentage
  ≥98%
• Soluble in
  Soluble in DMSO (15 mg/ml).
• Physical appearance
  White to beige powder.
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: D2B- Toxic Material Causing Other Toxic Effects, Severe eye irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H318- Causes serious eye damage. Precautionary statements: P280- Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• PubChem number
  51037431
• Scientific context
  Spautin-1 inhibits the deubiquitination activity of USP10 and USP13, two ubiquitin-specific peptidases. This results in the degradation of class III PI3 kinase complexes. Because this group of kinases regulates autophagy, Spautin-1 in turn inhibits autophagy.
• Bibliography
  1. Liu J., et al. (2011) Cell. 147(1): 223-34.
• Release date
  31-Mar-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Spautin-1 (SIH-404), a Autophagy inhibitor. CAS #: 1262888-28-7. Molecular Formula: C15H11F2N3. Molecular Weight: 271.26 g/mol. Chemical structure of Spautin-1, a Autophagy inhibitor (SIH-404). CAS # 1262888-28-7. Molecular Formula: C15H11F2N3.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.005
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Spautin-1   Autophagy   inhibitor  
• Short name
  Spautin-1, Autophagy inhibitor
• Alternative name
  Spautin-1, Autophagy suppressor

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