Urokinase,

Synonyms

Urokinase, Abbokinase, Urokinase-type Plasminogen Activator,uPA, EC 3.4.21.73, UK.
Alternative_names

Urokinase, Abbokinase, Urokinase-type Plasminogen Activator,uPA, EC 3.4.21.73, UK.
Description

A serine protease which activates zymogen
Recombinant

No
Source

Human urine
Purity by SDS PAGE

≥90%
Assay

SDS-PAGE
Purity

≥90%
Activity Specifications test method

1 nM UK will cause a change in absorbance of 0.001 at 405 nm in 1 minute at R/T in 100 µl reaction mixture containing 0.05 M Tris-HCl, 0.1 M NaCl, pH 7.4, using S2444 (0.6mM) as the substrate.
Molecular Weight

54.0 kDa
Storage Temp

-20°C
Shipping

Gel pack
Shelf Life

12 months
Appearance

Lyophilized protein
Physical form description

Lyophilized powder
Reconstitution Instructions

Reconstitute in sterile H₂O to a concentration >100 ug/ml. The solution can then be diluted into other aqueous solutions.
Background Information

Urokinase (UK) is a serine protease, which is one of biological plasminogen activators. It is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration, tissue remodeling, ovulation, and wound healing. It can be obtained from human urine or kidney cell culture. UK is a two-chain glycoprotein containing 411 amino acids with 12 dissulfide bonds. Its molecular weight is 54,000.
Handling

Centrifuge the vial prior to opening.
Usage

For Research Use Only! Not to be used in humans
Datasheet

Identity

HGNC:9053
Gene

PLAUR
Long gene name

plasminogen activator, urokinase receptor
Synonyms
- URKR
- UPAR
- CD87
Synonyms name
- urokinase-type plasminogen activator (uPA) receptor
- urokinase plasminogen activator surface receptor
Locus

19q13
Discovery year

1991-06-05
Entrez gene record

5329
RefSeq identity
- NM_002659
Classification
- LY6/PLAUR domain containing
- CD molecules
VEGA ID

OTTHUMG00000182778
Locus Specific Databases
- LRG_637