Rigosertib

  • Catalog number
    9482-25
  • Price
    Please ask
  • Size
    25 mg
  • Alternative_name
    Sodium (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetate; ON-01910
  • Description
    Rigosertib is a potent, specific PLK1 (Polo -Like Kinase 1) inhibitor (IC₅₀ = 9 nM). Rigosertib strongly inhibits the proliferation of cancer cell lines, with observed IC₅₀ values in the nanomolar range for both HeLa (115 nM) and C33A (45 nM) cells. In contrast, Rigosertib has a minimal effect on normal cell lines, BJ and Ect1/E6E7 (IC₅₀ > 0.1 mM).
  • CAS Number
    1225497-78-8
  • Structure Available
    Yes
  • Molecular Formula
    C₂₁H₂₄NNaO₈S
  • Molecular Weight
    473.47
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (>5 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    A potent, specific PLK1 (Polo -Like Kinase 1) inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    Gel pack
  • Shelf Life
    36 months
  • PubChem CID
    23696523
  • SMILES
    COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
  • InChi
    InChI=1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+;
  • InChi Key
    VLQLUZFVFXYXQE-USRGLUTNSA-M
  • MSDS Available
    Yes
  • Gene target
  • Short name
    Rigosertib
  • Alternative name
    Rigosertib
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