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Alternative_name
Sodium (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetate; ON-01910
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Description
Rigosertib is a potent, specific PLK1 (Polo -Like Kinase 1) inhibitor (IC₅₀ = 9 nM). Rigosertib strongly inhibits the proliferation of cancer cell lines, with observed IC₅₀ values in the nanomolar range for both HeLa (115 nM) and C33A (45 nM) cells. In contrast, Rigosertib has a minimal effect on normal cell lines, BJ and Ect1/E6E7 (IC₅₀ > 0.1 mM).
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CAS Number
1225497-78-8
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Structure Available
Yes
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Molecular Formula
C₂₁H₂₄NNaO₈S
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Molecular Weight
473.47
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (>5 mg/ml)
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Handling
Protect from air and light
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Tag Line
A potent, specific PLK1 (Polo -Like Kinase 1) inhibitor
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Storage Condition
-20°C
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Shipping Condition
Gel pack
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Shelf Life
36 months
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PubChem CID
23696523
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SMILES
COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
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InChi
InChI=1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+;
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InChi Key
VLQLUZFVFXYXQE-USRGLUTNSA-M
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MSDS Available
Yes