MCP-1 - Control Lysate

  • Catalog number
    X1243C
  • Price
    Please ask
  • Size
    20 μg
  • Category
    Other Reagents
  • Long description
    Monocyte chemotactic protein (MCP-1) is also known as monocyte chemotactic and activating factor (MCAF). It is the product of the human JE gene. The precursor form of MCP-1 consists of 99 amino acids with a signal peptide sequence consisting of 23 amino-terminal amino acids. The mature form of MCP-1 has 4 cysteine residues. The first two cysteine residues are in an adjacent position C-C, which characterizes MCP-1 as a member of the chemokine subfamily. MCP-1 is a nonglycosylated protein consisting of 76 amino acids with a molecular weight of 8700 daltons. MCP-1 mRNA expression can be induced in monocytes/macrophages, B lymphocytes, endothelial cells and astrocytoma cells by LPS. IL-1 will induce production of MCP-1 in fibroblasts, keratinocytes, hepatoma cells, and Type II pneumocytes. In vitro, MCP-1 will act on monocytes to initiate chemotaxis, induce superoxide anion release, induce the release of lysosomal enzymes and augment cytostatic activity. In vivo, MCP-1 will induce macrophage infiltration. The MCP-1 gene contains potential binding sites for several transcription factors, including AP-1, AP-2, NF-kB, and NF-IL6.
  • Antibody come from
    Hybridoma produced by the fusion of splenocytes from mice immunized with purified human keratin 7 isolated from HeLa cytoskeleton and mouse myeloma cells.
  • Other description
    Provided as solution in phosphate buffered saline with 0.08% sodium azide.
  • Clone
    not specified
  • Antigen antibody binding interaction
    MCP-1 - Control Lysate
  • Antibody is raised in
    see techfile
  • Antibody s reacts with
    see techfile
  • Antibody s reacts with these species
    This antibody doesn't cross react with other species
  • Antibody s specificity
    No Data Available
  • Application
    Activity Assay
  • Antibody s suited for
    Detects keratin 7 by Western blot. Detects a 54 kDa band corresponding to keratin 7. Optimal concentration should be evaluated by serial dilutions.
  • Storage
    -20ºC
  • Relevant references
    1. Neoplasma 1990, 37, 333-342_x000B__x000B_2. J. Tumor Marker Oncol. 1990, 5, 219_x000B__x000B_3. Int. J. Cancer 1988, Suppl. 3, 50-55
  • Protein number
    see ncbi
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Description
    Isotype or positive controls by peptides, antibodies and deactivated samples.
  • Gene target
    MCP-1   Lysate  
  • Gene symbol
    CCL2, CAPG, CCL13, CCL8, SLC25A33, CCR2, CD46, CCL7, IGHVII-1-1, MIR1-1
  • Short name
    MCP-1 - Control Lysate
  • Technique
    Control, controls
  • Isotype
    not specified
  • Label
    unlabeled
  • Alternative name
    MCP-1 - reference Lysate
  • Alternative technique
    controls
  • Tissue
    control, lysate
  • Virus
    lysate
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    C-C motif chemokine ligand 8
  • Synonyms gene
  • Synonyms gene name
    • small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)
    • chemokine (C-C motif) ligand 8
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1996-11-14
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Chemokine ligands
  • VEGA ID
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    CD46 molecule
  • Synonyms gene
  • Synonyms gene name
    • antigen identified by monoclonal antibody TRA-2-10
    • membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
    • CD46 antigen, complement regulatory protein
    • CD46 molecule, complement regulatory protein
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1988-08-31
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Sushi domain containing
    • Complement system regulators and receptors
    • CD molecules
  • VEGA ID
  • Locus Specific Databases
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin heavy variable (II)-1-1 (pseudogene)
  • Synonyms gene name
    • immunoglobulin heavy variable (II)-1-1
    • immunoglobulin heavy variable (II)-1-1 pseudogene
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-17
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin heavy locus at 14q32.33
  • VEGA ID
Gene info
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