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Category
Primary Antibodies
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Long description
It recognizes a polypeptide of 6.5kDa which is identified as pS2 estrogen-regulated protein. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy._x000B__x000B_
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Antibody come from
Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant human EP3 receptor protein and mouse myeloma cells.
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Other description
Provided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
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Clone
pS2.1
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Antigen antibody binding interaction
Mouse anti pS2 Estrogen-Regulated Protein Antibody
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Antibody is raised in
Mouse
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Antibody s reacts with
Human
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Antibody s reacts with these species
This antibody doesn't cross react with other species
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Antibody s specificity
No Data Available
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Application
Immunohistochemistry (Paraffin & Frozen Sections)
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Antibody s suited for
This antibody can be used for Western blot analysis (1-5 µg/ml). Optimal concentration should be evaluated by serial dilutions.
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Storage
-20ºC
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Relevant references
1. Strong, P. et al. Prostanoid-induced inhibition of lipolysis in rat isolated adipocytes: Probable involvement of EP3 receptors. Prostaglandins 1992, 43, 559-566_x000B__x000B_2. Coleman, R.A., et al. Classification of prostanoid receptors: Properties, distribution and structure of the receptors and their subtypes. Pharmacol. Rev. 1994, 46, 205-229_x000B__x000B_3. Zeng, L., et al. Regulation of expression of matrix metalloproteinase-9 in early human T cells of the HSB.2 cultured line by the EP3 subtype of prostaglandin E2 receptor. J. Biol. Chem. 1996, 271, 27744-27760_x000B__x000B_4. Beiche, F., et al. Localization of cyclooxygenase-2 and prostaglandin E2 receptor EP3 in the rat lumbar spinal cord. J. Neuroimmunol. 1998, 89, 26-34_x000B__x000B_5. Bhattacharya, M., et al. Nuclear prostaglandin receptors. Gene Ther. Mol. Biol. 1999, 4, 323-338_x000B__x000B_6. Morath, R., et al. Immunolocalization of the four prostaglandin E2 receptor proteins EP1, EP2, EP3 and EP4 in human kidney. J. Am. Soc. Nephrol. 1999, 10, 1851-1860_x000B__x000B_7. Nakamura, K., et al. Immunohistochemical localization of prostaglandin EP3 receptor in the rat hypothalamus. Neurosci. Lett. 1999, 260, 117-120_x000B__x000B_8. Nakamura, K., et al. Prostaglandin EP3 receptor protein in serotonin and catecholamine cell groups: a double immunoflourescence study in the rat brain. Neuroscience 2001, 103, 763-775
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Protein number
see ncbi
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Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
