AS-8351,KDM5B histone demethylase inhibitor
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Catalog numberSIH-558-2X5MG
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PricePlease ask
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Size2X5 mg
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Research Area sStem Cells
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CategorySmall Molecules
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Product TypeInhibitor
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CAS No796-42-9
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MolecularFormulaC17H13N3O2
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Molecular Weight291.3
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Purity>98% (TLC); NMR (Conforms)
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SolubilityMay be dissolved in DMSO (45 mg/ml); or ethanol (10 mg/ml, warm); or DMF (30 mg/ml)
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AppearanceYellow powder
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Storage Temperature-20°C
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Shipping TemperatureBlue Ice or 4ºC
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DescriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolKRT7-AS, DM1-AS, LRP1-AS, APOA1-AS, SIRT1-AS, ATXN2-AS, IRAIN, KDM5B, CTBP1-AS, HLA-B
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Short nameAS-8351 KDM5B histone demethylase inhibitor
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Alternative nameAS-8351,KDM5B histone demethylase suppressor
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Gene info
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Identity
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Gene
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Long gene nameKRT7 antisense RNA 1
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Locus
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Discovery year2016-11-18
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameDM1 locus antisense RNA
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Locus
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Discovery year2017-02-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
Gene info
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Identity
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Gene
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Long gene nameLRP1 antisense RNA
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Locus
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Discovery year2015-05-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameAPOA1 antisense RNA
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GenBank acession
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Locus
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Discovery year2014-01-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameSIRT1 antisense RNA
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Locus
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Discovery year2015-09-23
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Entrez gene record
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Pubmed identfication
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Classification
- Antisense RNAs
Gene info
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Identity
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Gene
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Long gene nameATXN2 antisense RNA
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Locus
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Discovery year2016-05-12
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Entrez gene record
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Pubmed identfication
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameIGF1R antisense imprinted non-protein coding RNA
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Synonyms
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Synonyms name
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Locus
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Discovery year2014-08-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Long non-coding RNAs with non-systematic symbols
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namelysine demethylase 5B
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Synonyms gene
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Synonyms gene name
- Jumonji, AT rich interactive domain 1B (RBP2-like)
- jumonji, AT rich interactive domain 1B
- lysine (K)-specific demethylase 5B
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-01-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- PHD finger proteins
- Lysine demethylases
- AT-rich interaction domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameCTBP1 antisense RNA
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2013-06-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class I, B
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Synonyms gene
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Synonyms gene name
- ankylosing spondylitis
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- Histocompatibility complex
- MicroRNA protein coding host genes
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VEGA ID
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Locus Specific Databases