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anti-Anti-Cyclin D1, Rabbit Monoclonal Antibody

anti-Anti-Cyclin D1, Rabbit Monoclonal Antibody is available 1 time from Biovision labs

A1129-50 | anti-Anti-Cyclin D1, Rabbit Monoclonal Antibody size: Anti-Cyclin D1, Rabbit Monoclonal Antibody | 427.97 USD

Catalog number A1129-50
Supplier Biovision
Price 427.97 USD
Size Anti-Cyclin D1, Rabbit Monoclonal Antibody
Product images
    #0#.jpegAnti-Cyclin D1, Rabbit Monoclonal Antibody
Target of this antibody: CCND1
Alternative names of antibody target: G1/S-specific cyclin-D1, B-cell lymphoma 1 protein, BCL-1, PRAD1
Background information: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Antibody host: Rabbit
Clonality of antibody: Monoclonal
Isotype: Rabbit IgG
Clone: RM241
This antibody reacts with: Human
Immunogene sequence: A peptide corresponding to Cyclin D1
Form of antibody: Liquid
Formulation of this antibody: In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification method: Affinity purified using protein A
This antibody has been succesfully tested for use in following methods: IHC, WB
Recommended usage: IHC: 1:500 -1:1000 dilution; WB: 1:1000 - 1:2000 dilution.
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
About Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.Rabbits are used for polyclonal antibody production by Biovision. Rabbit antibodies are very stable and can be stored for several days at room temperature. Biovision adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Latin name Oryctolagus cuniculus
French translation anticorps
Gene targetAnti-Cyclin Monoclonal
Short name anti-Anti-Cyclin D1, Rabbit Monoclonal Antibody
Technique Antibody, Rabbit, anti
Host Rabbit
Alternative name antibody to-Anti-Cyclin D1, production species: rabbit monoclonal (Antibody to)
Alternative technique antibodies
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