RANTES, human recombinant

• Catalog number
  4321-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  Small inducible cytokine A5, CCL5, T-cell-specific RANTES protein, SIS-delta, T cell- specific protein P228, TCP228, chemokine (C-C motif) ligand 5, SISd, SCYA5, RANTES, D17S136E, MGC17164.
• Alternative_names
  Small inducible cytokine A5, CCL5, T-cell-specific RANTES protein, SIS-delta, T cell- specific protein P228, TCP228, chemokine (C-C motif) ligand 5, SISd, SCYA5, RANTES, D17S136E, MGC17164.
• Description
  Chemokine for T cells, eosinophils, and basophils
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥98%
• Assay
  SDS-PAGE
• Purity
  ≥98%
• Biological activity
  Determined by its ability to chemoattract human blood monocytes using a concentration range of 1-10 ng/ml.
• Results
  1-10 ng/ml
• Molecular Weight
  10.1 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Lyophilized with no additives
• Reconstitution Instructions
  Reconstitute in H₂O to a concentration of 0.1-1 µg/µl. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°c for future use.
• Background Information
  RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  RANTES  
• Gene symbol
  CCL5
• Short name
  RANTES, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  RANTES, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:10632
• Gene
  CCL5
• Long gene name
  C-C motif chemokine ligand 5
• Synonyms gene
  • D17S136E
  • SCYA5
• Synonyms gene name
  • small inducible cytokine A5 (RANTES)
  • chemokine (C-C motif) ligand 5
• Synonyms
  • RANTES
  • SISd
  • TCP228
  • MGC17164
• Synonyms name
  • T-cell specific protein p288
  • T-cell specific RANTES protein
  • SIS-delta
  • regulated upon activation, normally T-expressed, and presumably secreted
  • beta-chemokine RANTES
  • small inducible cytokine subfamily A (Cys-Cys), member 5
• GenBank acession
  • AF043341
• Locus
  17q12
• Discovery year
  1990-07-05
• Entrez gene record
  6352
• Pubmed identfication
  • 1691736
• RefSeq identity
  • NM_002985
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000188396

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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