SYK Inhibitor, R406

• Catalog number
  9682-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
• Description
  R406 is a potent SYK (Spleen Tyrosine Kinase) inhibitor (IC₅₀ = 41 nM). R406 strongly inhibits SYK but not Lyn, and displays 5-fold less potency towards FLT3. R406 induces apoptosis in diffuse large B-cell lymphoma cell lines. It blocks B cell receptor signaling through inhibition of SYK autophosphorylation of Y525/Y526 and SYK-dependent phosphorylation of the B-cell linker protein.
• CAS Number
  841290-80-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₂H₂₃FN₆O₅
• Molecular Weight
  470.45
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>5 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent SYK (Spleen Tyrosine Kinase) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  11213558
• PubChem CID Link
• SMILES
  CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C
• InChi
  InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
• InChi Key
  NHHQJBCNYHBUSI-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  SYK   Inhibitor   R406  
• Gene symbol
  SYK
• Short name
  SYK Inhibitor, R406
• Alternative name
  spleen tyrosine kinase suppressor, R406
• Alternative to gene target
  spleen tyrosine kinase, p72-Syk, SYK and IDBG-75571 and ENSG00000165025 and 6850, transferase activity, Plasma membranes, Syk and IDBG-152695 and ENSMUSG00000021457 and 20963, SYK and IDBG-637026 and ENSBTAG00000004767 and 515515

Gene info

• Identity
  HGNC:11491
• Gene
  SYK
• Long gene name
  spleen associated tyrosine kinase
• Synonyms gene name
  • spleen tyrosine kinase
• GenBank acession
  • L28824
• Locus
  9q22.2
• Discovery year
  1994-12-13
• Entrez gene record
  6850
• Pubmed identfication
  • 8082894
  • 1423621
• Classification
  • Syk family tyrosine kinases
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000020200

Similar products