Rabbit anti-human-MMP-14 (MT1-MMP) (IgG), polyclonal

• Catalog number
  31 101 004
• Price
  Please ask
• Size
  100 µg/ 100 µl

• Antibody category
  Polyclonal Antibody
• Antibody s description
  Rabbit polyclonal antibody against human MMP 14. The polyclonal antibody was raised against a peptide derived from the hinge region between catalytic domain and hemopexin domain of MT1-MMP. For immunization a peptide-KLH-conjugate was used. and IgG fraction were purified by affinity chromatography on a peptide-BSA-matrix.
• Raised in
  Rabbit
• Research area of interest
  Diseases associated with MMP14 include Winchester Syndrome and Multicentric Osteolysis, Nodulosis, And Arthropathy. Among its related pathways are Signaling events mediated by focal adhesion kinase and Adhesion
• Package form
  liquid
• Clonality
  Polyclonal
• Antigen
  Peptide derived from the hinge region between catalytic domain and hemopexin domain of MT1-MMP.
• Reacts with
  Human
• Immunogen
  See the data sheet or contact us
• Contents
  20 mM Na-phosphate, pH 7.5, 150 mM NaCl containing 0.01 % thimerosal
• Purity
  >95%
• Tested applications
  • ELISA • Western-Blotting with ECL-Detection, suggested dilution 1 : 2000 to detect 100 ng MMP14
• Other names
  Rabbit polyclonal antibody against human MMP 14. The polyclonal antibody was raised against a peptide derived from the hinge region between catalytic domain and hemopexin domain of MT1-MMP. For immunization a peptide-KLH-conjugate was used. and IgG fraction were purified by affinity chromatography on a peptide-BSA-matrix.
• Crossreactivity
  no crossreactivty
• Antibody specificity
  The antibody is specific for MT1-MMP. It does not react to a significant extent with MT2-MMP.
• Purification
  peptide-BSA-matrix
• PubMed citations
  See the data sheet
• UniProt number
  P50281
• Storage conditions
  - 70°C
• Technical datasheet
  Contact us to receive the datasheet
• Representative figure
• Shipping condition
  dry ice
• Warnings
  For Research Use only.
• Other products
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Test
  biotez supplies antibodies that are for research of human proteins.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• About
  Immunoglobulin gamma, IgG, mouse monoclonal H&L chain clones or rabbit, goat polyclonal antibodies have 4 parts. There are 2 heavy chains, 2 light chains. The IgG antibody has 2 antigen binding sites. They represent 70% or more of serum antibodies. This antibody can be antigen purified or protein A or G purified. For storage sodium azide is added or you can call us to request azide free antibody preparations. These will need colder storage temperatures. Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera. Rabbits are used for polyclonal antibody production by biotez. Rabbit antibodies are very stable and can be stored for several days at room temperature. biotez adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Group
  Polyclonals and antibodies
• Latin name
  Oryctolagus cuniculus

• Gene target
  MMP-14   MT1-MMP  
• Gene symbol
  MMP14, MMP24, MMP28, MMP17, MMP15, MMP25, MMP16, MT1H, MT1F, MT1E
• Short name
  Rabbit anti- -MMP-14 (MT1-MMP) (IgG), polyclonal
• Technique
  anti-Human, Polyclonal, Rabbit, anti-, anti, IgG, antibody to, antibodies, antibodies against human proteins, IgGs, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Host
  Rabbit, Rabbits
• Isotype
  IgG, IgG
• Label
  not available conjugated
• Species
  Human, Humans
• Alternative name
  production species: rabbit Antibody tohuman-MMP-14 (MT1-MMP) (Immunoglobulin G), polyclonal
• Alternative technique
  polyclonals, rabbit-anti, antibodies, immunoglobulins

Gene info

• Identity
  HGNC:7160
• Gene
  MMP14
• Long gene name
  matrix metallopeptidase 14
• Synonyms gene name
  • matrix metalloproteinase 14 (membrane-inserted)
  • matrix metallopeptidase 14 (membrane-inserted)
• Synonyms
  • MT1-MMP
• Synonyms name
  • membrane type 1 metalloprotease
  • membrane type 1-matrix metalloproteinase
• Locus
  14q11.2
• Discovery year
  1994-11-20
• Entrez gene record
  4323
• Pubmed identfication
  • 8015608
• RefSeq identity
  • NM_004995
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000028704

Gene info

• Identity
  HGNC:7172
• Gene
  MMP24
• Long gene name
  matrix metallopeptidase 24
• Synonyms gene name
  • matrix metalloproteinase 24 (membrane-inserted)
  • matrix metallopeptidase 24 (membrane-inserted)
• Synonyms
  • MT5-MMP
• Synonyms name
  • membrane-type 5 matrix metalloproteinase
• GenBank acession
  • AF131284
• Locus
  20q11.22
• Discovery year
  1999-08-06
• Entrez gene record
  10893
• Pubmed identfication
  • 10363975
• RefSeq identity
  • NM_006690
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000032330

Gene info

• Identity
  HGNC:14366
• Gene
  MMP28
• Long gene name
  matrix metallopeptidase 28
• Synonyms gene name
  • matrix metalloproteinase 28
• Synonyms
  • MMP-25
  • MM28
  • EPILYSIN
  • MMP-28
• GenBank acession
  • AF315683
• Locus
  17q12
• Discovery year
  2001-01-09
• Entrez gene record
  79148
• Pubmed identfication
  • 11121398
  • 11255011
• RefSeq identity
  • NM_024302
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000188387

Gene info

• Identity
  HGNC:7163
• Gene
  MMP17
• Long gene name
  matrix metallopeptidase 17
• Synonyms gene name
  • matrix metalloproteinase 17 (membrane-inserted)
  • matrix metallopeptidase 17 (membrane-inserted)
• Synonyms
  • MT4-MMP
• GenBank acession
  • X89576
• Locus
  12q24.33
• Discovery year
  1996-11-13
• Entrez gene record
  4326
• Pubmed identfication
  • 9878265
• RefSeq identity
  • NM_016155
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000168050

Gene info

• Identity
  HGNC:7161
• Gene
  MMP15
• Long gene name
  matrix metallopeptidase 15
• Synonyms gene name
  • matrix metalloproteinase 15 (membrane-inserted)
  • matrix metallopeptidase 15 (membrane-inserted)
• Synonyms
  • MT2-MMP
  • MTMMP2
  • SMCP-2
• GenBank acession
  • Z48482
• Locus
  16q21
• Discovery year
  1996-11-13
• Entrez gene record
  4324
• Pubmed identfication
  • 9070935
  • 9119382
• RefSeq identity
  • NM_002428
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000133466

Gene info

• Identity
  HGNC:14246
• Gene
  MMP25
• Long gene name
  matrix metallopeptidase 25
• Synonyms gene
  • MMPL1
  • MMP20
• Synonyms gene name
  • matrix metalloproteinase 25
  • matrix metallopeptidase-like 1
• Synonyms
  • MT6-MMP
• GenBank acession
  • AF145442
• Locus
  16p13.3
• Discovery year
  2000-12-13
• Entrez gene record
  64386
• Pubmed identfication
  • 10628838
  • 10706098
• RefSeq identity
  • NM_022468
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000177475

Gene info

• Identity
  HGNC:7162
• Gene
  MMP16
• Long gene name
  matrix metallopeptidase 16
• Synonyms gene
  • C8orf57
• Synonyms gene name
  • matrix metalloproteinase 16 (membrane-inserted)
  • chromosome 8 open reading frame 57
  • matrix metallopeptidase 16 (membrane-inserted)
• Synonyms
  • MT3-MMP
  • DKFZp761D112
• GenBank acession
  • D85511
• Locus
  8q21.3
• Discovery year
  1996-11-13
• Entrez gene record
  4325
• Pubmed identfication
  • 7559440
• RefSeq identity
  • NM_005941
• Classification
  • M10 matrix metallopeptidases
• VEGA ID
  OTTHUMG00000163769

Gene info

• Identity
  HGNC:7400
• Gene
  MT1H
• Long gene name
  metallothionein 1H
• Synonyms gene
  • MT1
• GenBank acession
  • BC008408
• Locus
  16q13
• Discovery year
  1990-09-10
• Entrez gene record
  4496
• Pubmed identfication
  • 2286373
  • 8049263
• RefSeq identity
  • NM_005951
• Classification
  • Metallothioneins
• VEGA ID
  OTTHUMG00000133283

Gene info

• Identity
  HGNC:7398
• Gene
  MT1F
• Long gene name
  metallothionein 1F
• Synonyms gene
  • MT1
• GenBank acession
  • BC029453
• Locus
  16q13
• Discovery year
  1990-09-10
• Entrez gene record
  4494
• Pubmed identfication
  • 6089206
  • 2581970
• RefSeq identity
  • NM_005949
• Classification
  • Metallothioneins
• VEGA ID
  OTTHUMG00000176838

Gene info

• Identity
  HGNC:7397
• Gene
  MT1E
• Long gene name
  metallothionein 1E
• Synonyms gene
  • MT1
• Synonyms
  • MTD
• GenBank acession
  • BC009699
• Locus
  16q13
• Discovery year
  1990-09-10
• Entrez gene record
  4493
• Pubmed identfication
  • 6089206
  • 2581970
• RefSeq identity
  • NM_175617
• Classification
  • Metallothioneins
• VEGA ID
  OTTHUMG00000133014

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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