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Alternative_name
(10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride; XI-011
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Description
Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.
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CAS Number
59474-01-0
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₇H₁₆N₂S.HCl
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Molecular Weight
316.85
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (100 mM) or EtOH (10 mM)
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Handling
Protect from moisture
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Tag Line
A p53 activator
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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PubChem CID
16759161
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SMILES
CC1=C2C=CC=CC2=C(C3=CC=CC=C13)CSC(=N)N.Cl
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InChi
InChI=1S/C17H16N2S.ClH/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5- 3-7-13(11)15;/h2-9H,10H2,1H3,(H3,18,19);1H
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InChi Key
VIBMUYOXJUCEMA-UHFFFAOYSA-N
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MSDS Available
Yes
