PI3-Kɣ Inhibitor, AS-605240

• Catalog number
  1780-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
• Description
  Cell-permeable. A potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC₅₀ = 8 nM). Displays >33-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα.
• CAS Number
  648450-29-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₂H₇N₃O₂S
• Molecular Weight
  257.27
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO ( 1 mM)
• Handling
  Protect from air and light
• Tag Line
  A potent inhibitor of PI 3-kinase γ (PI3Kγ)
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  48 months
• MDL Number
  MFCD11100415
• PubChem CID
  5289247
• PubChem CID Link
• SMILES
  C1=CC2=NC=CN=C2C=C1C=C3C(=O)NC(=O)S3
• InChi
  InChI=1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6-
• InChi Key
  SQWZFLMPDUSYGV-POHAHGRESA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  PI3-Kɣ   Inhibitor   AS-605240  
• Gene symbol
  PIK3C2B, PIK3CA, PIK3C2A, H4C13, PIK3R5, TUBA1B, KRT7-AS, DM1-AS, RAP2A
• Short name
  PI3-Kɣ Inhibitor, AS-605240
• Alternative name
  PI3-Kɣ suppressor, AS-605240

Gene info

• Identity
  HGNC:8972
• Gene
  PIK3C2B
• Long gene name
  phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
• Synonyms gene name
  • phosphoinositide-3-kinase, class 2, beta polypeptide
  • phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
• Synonyms
  • C2-PI3K
  • PI3K-C2beta
• GenBank acession
  • Y11312
• Locus
  1q32.1
• Discovery year
  1998-05-21
• Entrez gene record
  5287
• Pubmed identfication
  • 9144573
  • 9830063
• RefSeq identity
  • NM_002646
• Classification
  • Phosphatidylinositol 3-kinase subunits
• VEGA ID
  OTTHUMG00000036101

Gene info

• Identity
  HGNC:8975
• Gene
  PIK3CA
• Long gene name
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
• Synonyms gene name
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
• Synonyms
  • PI3K
• Locus
  3q26.32
• Discovery year
  1994-07-15
• Entrez gene record
  5290
• Pubmed identfication
  • 1322797
• Classification
  • Phosphatidylinositol 3-kinase subunits
• VEGA ID
  OTTHUMG00000157311
• Locus Specific Databases
  • LRG_310

Gene info

• Identity
  HGNC:8971
• Gene
  PIK3C2A
• Long gene name
  phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
• Synonyms gene name
  • phosphoinositide-3-kinase, class 2, alpha polypeptide
  • phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
• Synonyms
  • PI3K-C2alpha
• GenBank acession
  • Y13367
• Locus
  11p15.1
• Discovery year
  1998-05-21
• Entrez gene record
  5286
• Pubmed identfication
  • 9337861
• RefSeq identity
  • NM_002645
• Classification
  • Phosphatidylinositol 3-kinase subunits
• VEGA ID
  OTTHUMG00000166036

Gene info

• Identity
  HGNC:4791
• Gene
  H4C13
• Long gene name
  H4 clustered histone 13
• Synonyms gene
  • H4FK
  • HIST1H4L
• Synonyms gene name
  • H4 histone family, member K
  • histone 1, H4l
  • histone cluster 1, H4l
  • histone cluster 1 H4 family member l
• Synonyms
  • H4.k
  • H4/k
• GenBank acession
  • X83548
• Locus
  6p22.1
• Discovery year
  1998-09-07
• Entrez gene record
  8368
• Pubmed identfication
  • 9031620
  • 9439656
  • 12408966
• RefSeq identity
  • NM_003546
• Classification
  • H4 histones
• VEGA ID
  OTTHUMG00000016211

Gene info

• Identity
  HGNC:30035
• Gene
  PIK3R5
• Long gene name
  phosphoinositide-3-kinase regulatory subunit 5
• Synonyms gene name
  • phosphoinositide-3-kinase, regulatory subunit 5
• Synonyms
  • P101-PI3K
  • p101
• GenBank acession
  • AF128881
• Locus
  17p13.1
• Discovery year
  2004-10-13
• Entrez gene record
  23533
• Pubmed identfication
  • 12507995
• RefSeq identity
  • NM_014308
• VEGA ID
  OTTHUMG00000108197

Gene info

• Identity
  HGNC:18809
• Gene
  TUBA1B
• Long gene name
  tubulin alpha 1b
• Synonyms
  • K-ALPHA-1
• Synonyms name
  • tubulin, alpha, ubiquitous
• GenBank acession
  • AF081484
• Locus
  12q13.12
• Discovery year
  2007-02-12
• Entrez gene record
  10376
• Pubmed identfication
  • 12054644
  • 6646120
• RefSeq identity
  • NM_006082
• Classification
  • Tubulins
• VEGA ID
  OTTHUMG00000170410

Gene info

• Identity
  HGNC:52643
• Gene
  KRT7-AS
• Long gene name
  KRT7 antisense RNA 1
• Locus
  12q13.13
• Discovery year
  2016-11-18
• Entrez gene record
  109729127
• Pubmed identfication
  • 26876208
• RefSeq identity
  • NR_146274
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000169581

Gene info

• Identity
  HGNC:53125
• Gene
  DM1-AS
• Long gene name
  DM1 locus antisense RNA
• Locus
  19q13.32
• Discovery year
  2017-02-16
• Entrez gene record
  109729182
• Pubmed identfication
  • 28102759
• RefSeq identity
  • NR_147193
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:9861
• Gene
  RAP2A
• Long gene name
  RAP2A, member of RAS oncogene family
• Synonyms gene
  • RAP2
• Synonyms
  • K-REV
• GenBank acession
  • AF205602
• Locus
  13q32.1
• Discovery year
  1989-06-30
• Entrez gene record
  5911
• Classification
  • RAS type GTPase family
• VEGA ID
  OTTHUMG00000017240

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