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Gene info
MUC4 is a membrane-associated protein of the mucin (MUC) gene family, encoded by a gene on chromosome 3q29 and produced by epithelial cells as a heterodimer. The MUC4 protein is thought to play a protective role for vulnerable epithelia, particularly in the airway, eye, female reproductive tract and mammary gland. Two observations support this hypothesis: (a) MUC4 acts as an anti-adhesive barrier at epithelial and tumor surfaces, and (b) MUC4 binds the receptor tyrosine kinase ErbB2, and can alter its downstream signaling. Alterations in MUC4 expression have been observed in association with a variety of inflammatory and neoplastic states; reduction or loss has been reported in non-small cell lung carcinoma, hyperplastic polyps of the colon, and serrated colon adenomas, while overexpression of the MUC4/Sialomucin complex (SMC) has been identified in malignant progression of mammary tumors in both humans and rats. Suitable for use in Immunohistochemistry. Other applications have not been tested. Recognizes rat MUC4. In normal tissues, stains stomach, colon, and the endothelial cells of small blood vessels and capillaries. In abnormal tissues, this antibody exhibits strong positive staining in colon polyps (3/3 specimens tested), colon carcinoma (4/4), and gastric adenocarcinoma (4/5). Lung adenocarcinoma and ovarian mucinous adenocarcinoma also demonstrated positive staining. Species Crossreactivity: human.
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Gene names
MUC4, ASGP, HSA276359, Mucin-4, Testis mucin, Tracheobronchial mucin, Ascites sialoglycoprotein, MUC-4, Mucin 4, tracheobronchial
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Antibodie s label
unlabelled serum
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Purity
Purified
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Ab raised in
Mouse
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Type
Monoclonal
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Monoclonal
[1G8]
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Immunoglobulin
IgG1
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Spicific to
In normal tissues, stains stomach, colon, and the endothelial cells of small blood vessels and capillaries. In abnormal tissues, This antibody exhibits strong positive staining in colon polyps (3/3 specimens tested).
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Antigen
Mucin 4 monoclonal antibody was made against Mucin 4 (Rat).
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Immuno application
immuno-histo-chemistry
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Antibody advice
Mucin 4 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 10 ug/mL.
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Suspention pH azide
PBS, pH 7.4, 1% BSA, 0.1% sodium azide.
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Keep at
Store Mucin 4 antibody at 4 grades C or -20 grades C. As with all antibodies avoid freeze/thaw cycles.
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Works with
Human, Rat
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Ncbi nr
A0T3F4
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Vial with antibody
in solution
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NCBI GENE nr
4585
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GENE symbol
MUC4
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Antigene name
mucin 4, cell surface associated
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Source
Homo sapiens
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Protein nr
A0T3F4
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps