anti-Mucin 4 Antibody [1G8]

  • Catalog number
    49-936
  • Price
    Please ask
  • Size
    0.1 mL
  • Gene info
    MUC4 is a membrane-associated protein of the mucin (MUC) gene family, encoded by a gene on chromosome 3q29 and produced by epithelial cells as a heterodimer. The MUC4 protein is thought to play a protective role for vulnerable epithelia, particularly in the airway, eye, female reproductive tract and mammary gland. Two observations support this hypothesis: (a) MUC4 acts as an anti-adhesive barrier at epithelial and tumor surfaces, and (b) MUC4 binds the receptor tyrosine kinase ErbB2, and can alter its downstream signaling. Alterations in MUC4 expression have been observed in association with a variety of inflammatory and neoplastic states; reduction or loss has been reported in non-small cell lung carcinoma, hyperplastic polyps of the colon, and serrated colon adenomas, while overexpression of the MUC4/Sialomucin complex (SMC) has been identified in malignant progression of mammary tumors in both humans and rats. Suitable for use in Immunohistochemistry. Other applications have not been tested. Recognizes rat MUC4. In normal tissues, stains stomach, colon, and the endothelial cells of small blood vessels and capillaries. In abnormal tissues, this antibody exhibits strong positive staining in colon polyps (3/3 specimens tested), colon carcinoma (4/4), and gastric adenocarcinoma (4/5). Lung adenocarcinoma and ovarian mucinous adenocarcinoma also demonstrated positive staining. Species Crossreactivity: human.
  • Gene names
    MUC4, ASGP, HSA276359, Mucin-4, Testis mucin, Tracheobronchial mucin, Ascites sialoglycoprotein, MUC-4, Mucin 4, tracheobronchial
  • Antibodie s label
    unlabelled serum
  • Purity
    Purified
  • Ab raised in
    Mouse
  • Type
    Monoclonal
  • Monoclonal
    [1G8]
  • Immunoglobulin
    IgG1
  • Spicific to
    In normal tissues, stains stomach, colon, and the endothelial cells of small blood vessels and capillaries. In abnormal tissues, This antibody exhibits strong positive staining in colon polyps (3/3 specimens tested).
  • Antigen
    Mucin 4 monoclonal antibody was made against Mucin 4 (Rat).
  • Immuno application
    immuno-histo-chemistry
  • Antibody advice
    Mucin 4 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 10 ug/mL.
  • Suspention pH azide
    PBS, pH 7.4, 1% BSA, 0.1% sodium azide.
  • Keep at
    Store Mucin 4 antibody at 4 grades C or -20 grades C. As with all antibodies avoid freeze/thaw cycles.
  • Works with
    Human, Rat
  • Ncbi nr
    A0T3F4
  • Vial with antibody
    in solution
  • NCBI GENE nr
    4585
  • GENE symbol
    MUC4
  • Antigene name
    mucin 4, cell surface associated
  • Source
    Homo sapiens
  • Protein nr
    A0T3F4
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
  • Properties
    If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
    Mucin   [1G8]  
  • Short name
    anti-Mucin 4 Antibody [1G8]
  • Technique
    Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
  • Alternative name
    Antibody toMucin 4 (antibody to-) [1G8]
  • Alternative technique
    antibodies
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Similar products
Filters
Contact
Chat with gentaur.com employee