Human CellExp™ Osteoprotegerin / TNFRSF11B, human recombinant

  • Catalog number
    7514-20
  • Price
    Please ask
  • Size
    20 ug
  • Synonyms
    TNFRSF11B, OCIF, OPG, Osteoprotegerin
  • Alternative_names
    TNFRSF11B, OCIF, OPG, Osteoprotegerin
  • Description
    ≥95% pure, active, human cell expressed, human recombinant Osteoprotegerin / TNFRSF11B - acts as decoy receptor for TNFSF11/RANKL
  • Recombinant
    Yes
  • Source
    HEK293 cells
  • Purity by SDS PAGE
    ≥95%
  • Assay
    SDS-PAGE
  • Biological activity
    Measured by its binding ability in a functional ELISA. Immobilized rh TNFRSF11B at 10 ug/ml (100 ul/well) can bind human TNFSF11 Fc Chimera with a linear ranger of 4-256 ng/ml.
  • Molecular Weight
    This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 44.4 kDa. The predicted N-terminus is Glu 22. DTT-reduced Protein migrates as 55 kDa due to glycosylation.
  • Storage Temp
    -20°C
  • Shipping
    Gel Pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized
  • Physical form description
    Lyophilized from 0.22 um filtered solution in PBS, pH 7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
  • Reconstitution Instructions
    Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.
  • Background Information
    Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    TNFRSF11B, BTF3P11
  • Short name
    CellExp™ Osteoprotegerin / TNFRSF11B, recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Species
    Humans
  • Alternative name
    H. sapiens CellExp™ Osteoprotegerin / tumor necrosis factor receptor superfamily, member 11b, H. sapiens Rec.
  • Alternative technique
    rec
  • Alternative to gene target
    tumor necrosis factor receptor superfamily, member 11b, OCIF and OPG and TR1, TNFRSF11B and IDBG-33675 and ENSG00000164761 and 4982, protein binding, Extracellular, Tnfrsf11b and IDBG-140472 and ENSMUSG00000063727 and 18383, TNFRSF11B and IDBG-644876 and ENSBTAG00000007423 and 523822
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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