AG-221 (Enasidenib)
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Catalog numberB1070-25
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PricePlease ask
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Size25 mg
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Alternative_name2-methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)-6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)amino)propan-2-ol
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DescriptionAG-221(Enasidenib) is a potent, selective, and reversible inhibitor of mutant IDH2 (isocitrate dehydrogenase type 2). It specifically inhibits IDH2 in the mitochondria, blocking the formation of oncometabolite 2-hydroxyglutarate (2HG). In in vitro studies, AG-221 reduces 2-HG levels by >90%, reverses histone and DNA hypermethylation, and induces cellular differentiation in leukemia cell models.
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CAS Number1446502-11-9
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₉H₁₇F₆N₇O
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Molecular Weight473.38
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>30 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent IDH2 (Isocitrate dehydrogenase 2) inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID89683805
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SMILESCC(C)(CNC1=NC(=NC(=N1)NC2=CC(=NC=C2)C(F)(F)F)C3=NC(=CC=C3)C(F)(F)F)O
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InChiInChI=1S/C19H17F6N7O/c1-17(2,33)9-27-15-30-14(11-4-3-5-12(29-11)18(20,21)22)31-16(32-15)28-10-6-7-26-13(8-10)19(23,24)25/h3-8,33H,9H2,1-2H3,(H2,26,27,28,30,31,32)
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InChi KeyDYLUUSLLRIQKOE-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolTPBG, MIR221, BCAP31
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Short nameAG-221 (Enasidenib)
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Alternative nameAG-221 (Enasidenib)
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Gene info
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Identity
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Gene
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Long gene nametrophoblast glycoprotein
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Synonyms
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GenBank acession
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Locus
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Discovery year1990-10-16
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 221
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNAs
Gene info
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Identity
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Gene
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Long gene nameB cell receptor associated protein 31
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-12-22
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Entrez gene record
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RefSeq identity
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VEGA ID