AG-221 (Enasidenib)

  • Catalog number
    B1070-25
  • Price
    Please ask
  • Size
    25 mg
  • Alternative_name
    2-methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)-6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)amino)propan-2-ol
  • Description
    AG-221(Enasidenib) is a potent, selective, and reversible inhibitor of mutant IDH2 (isocitrate dehydrogenase type 2). It specifically inhibits IDH2 in the mitochondria, blocking the formation of oncometabolite 2-hydroxyglutarate (2HG). In in vitro studies, AG-221 reduces 2-HG levels by >90%, reverses histone and DNA hypermethylation, and induces cellular differentiation in leukemia cell models.
  • CAS Number
    1446502-11-9
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₁₉H₁₇F₆N₇O
  • Molecular Weight
    473.38
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (>30 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    A potent IDH2 (Isocitrate dehydrogenase 2) inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • PubChem CID
    89683805
  • SMILES
    CC(C)(CNC1=NC(=NC(=N1)NC2=CC(=NC=C2)C(F)(F)F)C3=NC(=CC=C3)C(F)(F)F)O
  • InChi
    InChI=1S/C19H17F6N7O/c1-17(2,33)9-27-15-30-14(11-4-3-5-12(29-11)18(20,21)22)31-16(32-15)28-10-6-7-26-13(8-10)19(23,24)25/h3-8,33H,9H2,1-2H3,(H2,26,27,28,30,31,32)
  • InChi Key
    DYLUUSLLRIQKOE-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
  • Gene symbol
    TPBG, MIR221, BCAP31
  • Short name
    AG-221 (Enasidenib)
  • Alternative name
    AG-221 (Enasidenib)
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