Soluble Receptor Activator of NF-Kappa B (sRANK Ligand) Human

Data Sheet URL
Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Description

FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Gene target

Soluble Receptor Activator NF-Kappa sRANK Ligand
Gene symbol

NFE4, NFE2, NEFH, NFKB1, INA, NFASC, NFATC1, NFATC2, NFYC, NFIL3
Short name

Soluble Receptor Activator of NF-Kappa B (sRANK Ligand)
Species

Human, Humans
Alternative name

Soluble Receptor Activator on NF-Kappa B (sRANK Ligand) H. sapiens

Identity

HGNC:7780
Gene

NFE2
Long gene name

nuclear factor, erythroid 2
Synonyms gene name
- nuclear factor (erythroid-derived 2), 45kD
- nuclear factor (erythroid-derived 2), 45kDa
Synonyms
- NF-E2
GenBank acession
- BC005044
Locus

12q13.13
Discovery year

1993-11-03
Entrez gene record

4778
Pubmed identfication
- 8355703
RefSeq identity
- NM_006163
Classification
- Basic leucine zipper proteins
VEGA ID

OTTHUMG00000169761

Identity

HGNC:7737
Gene

NEFH
Long gene name

neurofilament heavy chain
Synonyms gene name
- neurofilament, heavy polypeptide 200kDa
- neurofilament heavy polypeptide
- neurofilament heavy
Synonyms
- NF-H
- NFH
Locus

22q12.2
Discovery year

1988-08-31
Entrez gene record

4744
RefSeq identity
- NM_021076
Classification
- Intermediate filaments Type IV
VEGA ID

OTTHUMG00000151155
Locus Specific Databases
- ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

Identity

HGNC:7794
Gene

NFKB1
Long gene name

nuclear factor kappa B subunit 1
Synonyms gene name
- nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Synonyms
- KBF1
- p105
- NFKB-p50
- p50
- NF-kappaB
- NFkappaB
- NF-kB1
Synonyms name
- Nuclear factor NF-kappa-B p105 subunit
GenBank acession
- M58603
Locus

4q24
Discovery year

1991-11-14
Entrez gene record

4790
Pubmed identfication
- 1992489
RefSeq identity
- NM_003998
Classification
- NF-kappa B complex subunits
- Ankyrin repeat domain containing
- IPT domain containing
VEGA ID

OTTHUMG00000161080
Locus Specific Databases
- LRG_1316

Identity

HGNC:29866
Gene

NFASC
Long gene name

neurofascin
Synonyms gene name
- neurofascin homolog (chicken)
Synonyms
- NRCAML
- KIAA0756
- FLJ46866
- NF
GenBank acession
- AK027553
Locus

1q32.1
Discovery year

2005-11-22
Entrez gene record

23114
Pubmed identfication
- 1377696
- 8672144
RefSeq identity
- NM_001005388
Classification
- Ig-like cell adhesion molecule family
- I-set domain containing
- Fibronectin type III domain containing
VEGA ID

OTTHUMG00000151697

Identity

HGNC:7775
Gene

NFATC1
Long gene name

nuclear factor of activated T cells 1
Synonyms gene name
- nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
- nuclear factor of activated T-cells 1
Synonyms
- NF-ATC
- NFATc
- NFAT2
GenBank acession
- U08015
Locus

18q23
Discovery year

1994-11-16
Entrez gene record

4772
Pubmed identfication
- 8202141
RefSeq identity
- NM_172390
Classification
- Nuclear factors of activated T-cells
- IPT domain containing
VEGA ID

OTTHUMG00000132897

Identity

HGNC:7776
Gene

NFATC2
Long gene name

nuclear factor of activated T cells 2
Synonyms gene name
- nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
- nuclear factor of activated T-cells 2
Synonyms
- NF-ATP
- NFATp
- NFAT1
GenBank acession
- U43342
- U43341
Locus

20q13.2
Discovery year

1994-11-16
Entrez gene record

4773
Pubmed identfication
- 8202141
RefSeq identity
- NM_012340
Classification
- IPT domain containing
- Nuclear factors of activated T-cells
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000032747

Identity

HGNC:7787
Gene

NFIL3
Long gene name

nuclear factor, interleukin 3 regulated
Synonyms gene
- IL3BP1
Synonyms gene name
- interleukin-3 binding protein 1
Synonyms
- E4BP4
- NFIL3A
- NF-IL3A
Synonyms name
- E4 promoter-binding protein
- adenovirus E4 promoter region binding protein
GenBank acession
- X64318
Locus

9q22.31
Discovery year

1995-02-13
Entrez gene record

4783
Pubmed identfication
- 7565758
- 1620116
RefSeq identity
- NM_005384
Classification
- Basic leucine zipper proteins
VEGA ID

OTTHUMG00000020209