BMPR-1A, BMP-R1A, BMPR1A, BMR1A, CD292, CD-292
BMPR-1A, BMP-R1A, BMPR1A, BMR1A, CD292, CD-292, Activin receptor-like kinase 3, Serine/threonine-protein kinase receptor R5, CD_antigen=CD292
A transmembrane serine/threonine kinases
Insect cells (Baculovirus)
Purity by SDS-PAGE
Measured by its ability to inhibit recombinant human BMP-2 induced alkaline phosphatase production by C2C12 myogenic cells. The ED₅₀ for this effect is typically 1-3 µg/ml in the presence of 500 ng/ml of recombinant human BMP-2.
Physical form description
Lyophilized from sterile PBS.
Centrifuge the vial prior to opening. Reconstitute in sterile PBS to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers.
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the Activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1A Human Recombinant extracellular domain produced in baculovirus is a monomeric, glycosylated, polypeptide chain fused with 6xHis tag at C-terminus and having a molecular mass of 23 kDa. The BMR1A is purified by proprietary chromatographic techniques.
Centrifuge the vial prior to opening.
For Research Use Only! Not to be used in humans
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Recombinants or rec. proteins
bone morphogenetic protein receptor, classification IA, H. sapiens recombinant
Alternative to gene target
bone morphogenetic protein receptor, type IA, 10q23del and ACVRLK3 and ALK3 and CD292 and SKR5, BMPR1A and IDBG-81081 and ENSG00000107779 and 657, transferase activity, Cell surfaces, Bmpr1a and IDBG-149689 and ENSMUSG00000021796 and 12166, BT.48514 and IDBG-631434 and ENSBTAG00000000231 and 404101