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Rabbit Anti Human SLC6A8 Polyclonal

Rabbit Anti Human SLC6A8 Polyclonal is available 18 times from Stressmark antibodies labs

SPC-1333D-ALP | Rabbit Anti-Human SLC6A8 Polyclonal: Alkaline Phosphatase size: 100 µl | 402.29 USD

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SPC-1333D-APC | Rabbit Anti-Human SLC6A8 Polyclonal: APC size: 100 µl | 409.19 USD

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SPC-1333D-A390 | Rabbit Anti-Human SLC6A8 Polyclonal: ATTO 390 size: 100 µl | 411.49 USD

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SPC-1333D-A488 | Rabbit Anti-Human SLC6A8 Polyclonal: ATTO 488 size: 100 µl | 410.34 USD

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SPC-1333D-A565 | Rabbit Anti-Human SLC6A8 Polyclonal: ATTO 565 size: 100 µl | 410.34 USD

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SPC-1333D-A594 | Rabbit Anti-Human SLC6A8 Polyclonal: ATTO 594 size: 100 µl | 410.34 USD

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SPC-1333D-A633 | Rabbit Anti-Human SLC6A8 Polyclonal: ATTO 633 size: 100 µl | 410.34 USD

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SPC-1333D-A655 | Rabbit Anti-Human SLC6A8 Polyclonal: ATTO 655 size: 100 µl | 410.34 USD

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SPC-1333D-A680 | Rabbit Anti-Human SLC6A8 Polyclonal: ATTO 680 size: 100 µl | 410.34 USD

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SPC-1333D-A700 | Rabbit Anti-Human SLC6A8 Polyclonal: ATTO 700 size: 100 µl | 410.34 USD

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SPC-1333D-BI | Rabbit Anti-Human SLC6A8 Polyclonal: Biotin size: 100 µl | 404.59 USD

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SPC-1333D-FITC | Rabbit Anti-Human SLC6A8 Polyclonal: FITC size: 100 µl | 399.99 USD

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SPC-1333D-HRP | Rabbit Anti-Human SLC6A8 Polyclonal: HRP size: 100 µl | 395.39 USD

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SPC-1333D-P594 | Rabbit Anti-Human SLC6A8 Polyclonal: PE/ATTO 594 size: 100 µl | 418.38 USD

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SPC-1333D-PCP | Rabbit Anti-Human SLC6A8 Polyclonal: PerCP size: 100 µl | 409.19 USD

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SPC-1333D-RPE | Rabbit Anti-Human SLC6A8 Polyclonal: RPE size: 100 µl | 405.74 USD

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SPC-1333D-STR | Rabbit Anti-Human SLC6A8 Polyclonal: Streptavidin size: 100 µl | 408.04 USD

Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Test StressMark antibodies supplies antibodies that are for research of human proteins.
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Group Polyclonals and antibodies
About Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Latin name Oryctolagus cuniculus
Gene targetSLC6A8 Streptavidin
Short name Rabbit Anti- SLC6A8 Polyclonal: Streptavidin
Technique anti-Human, Polyclonal, Rabbit, anti
Label streptavidin
Alternative name production species: rabbit antibody to-H. sapiens SLC6A8 polyclonal: biotinilated-binding streptavidin
1. Gene info
Identity11055
GeneSLC6A8
Long gene name solute carrier family 6 member 8
Synonyms gene name
  • solute carrier family 6 (neurotransmitter transporter, creatine), member 8
  • solute carrier family 6 (neurotransmitter transporter), member 8
Synonyms
LocusXq28
Discovery year 1994-12-19
Entrez gene record6535
Pubmed identfication
Classification
  • Solute carriers
Havana BLAST/BLATOTTHUMG00000024208
MeSH Data
Concept
Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Additional information
PubMedX-linked creatine deficiency syndrome: a novel mutation in creatine transporter gene SLC6A8.
This study reveals the presence of a novel SLC6A8 splice variant, SLC6A8C in human and mouse.
The estimated amount of total creatine in the placenta and brain significantly increased in the second half of pregnancy, coinciding with a significant increase in expression of CrT mRNA.
Guanidinoacetate is transported from AGAT- to GAMT-expressing cells through SLC6A8 to allow creatine synthesis, thereby explaining creatine deficiency in SLC6A8-deficient CNS.
Hemizygosity for a novel deletion producing a frameshift (c.974_975delCA, p.Thr325SerfsX139) in the creatine transporter gene is associated with X-linked cerebral creatine deficiency.
Heterozygous SLC6A8 deficiency is a potentially treatable condition and should be considered in females with intractable epilepsy and developmental delay/intellectual disabilit
Missense mutations in SLC6A8 gene is associated with X-linked disorder.
Creatine transporter deficiency is a relatively common genetic disorder in males with sporadic or familiar mental retardation and diagnostic screening of them should always include screening for SLC6A8 deficiency.
CTR4 and CTR5 are possible regulators of the creatine transporter since their overexpression results in upregulated CTR1 protein and creatine uptake.
both BCAP31 and ABCD1 were associated with hepatic cholestasis and death before 1 year. Remarkably, a patient with an isolated deletion at the 3'-end of SLC6A8 had a similar severe phenotype as seen in BCAP31 deficiency
Product images
    #Human#.jpg

SPC-1333D | Rabbit Anti-Human SLC6A8 Polyclonal: Unconjugated size: 100 µl | 355.16 USD

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PubMed number Refer to PubMed
Net weight (g) 0.1
Recommended buffer for storage PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Antibody's reactivity Human, Mouse, Rat
Warning information Non-hazardous
Representative figure legend Western blot analysis of Human HuvEc cell lysates showing detection of ~70kDa SLC6A8 protein using Rabbit Anti-SLC6A8 Polyclonal Antibody (SPC-1333). Lane 1: Human HUVEC cells. Lane 2: Human HUVEC cells treated with the immunizing peptide. Primary Antibody: Rabbit Anti-SLC6A8 Polyclonal Antibody (SPC-1333) at 1:1000. Predicted/Observed Size: ~70kDa. Rabbit Anti-SLC6A8 Antibody used in Western blot (WB) on HuvEc cell lysates (SPC-1333)
Raised in Rabbit
NCBI number NP_005620.1
Gene number 6535
Released date 6/Sep/2016
Immunogen Synthesized peptide derived from C-terminal of human SLC6A8.
Antibody's other name SLC6A 8 Antibody, Creatine transporter 1 Antibody, CRTR Antibody, CT1 Antibody, Sodium and chloride-dependent creatine transporter 1 Antibody, Solute carrier family 6 member 8 Antibody
Protein number P48029
Antibody's recommended dilutions for use WB (1:1000), ELISA (1:10000); optimal dilutions for assays should be determined by the user.
Tested applications To be tested
Primary research fields Cell Signaling
Antibody's datasheet Contact our support service to receive datasheet or other technical documentation.
Total weight (kg) 1.4
Stock availabilit In Stock
Scientific context SLC6A8 is required for the uptake of creatine in muscles and brain. Deficiency of this gene is an X-linked form of intellectual diavility and is the most common casue of cerebral creatine syndromes.
Antibody's target Human SLC6A8
Certificate of analysis A 1:1000 dilution of SPC-1333 was sufficient for detection of SLC6A8 in 10 µg of HuvEc cell lysates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.
Tissue specificity Predominantly expressed in skeletal muscle and kidney. Also found in brain, heart, colon, testis and prostate.
Antibody's full description Rabbit Anti-Human SLC6A8 Polyclonal
Country of production Canada
Antibody's purified from Peptide Affinity Purified
Antibody's concentration See included datasheet or contact our support service
Tested reactivity To be tested
Antibody in cell Membrane
Antibody's category Polyclonal Antibodies
Bibliography 1. more
Verified applications WB, ELISA
Antibody's specificity Detects ~70kDa, endogenous levels of total SLC6A8 protein.
Storage recommendations -20°C
Shipping recommendations Blue Ice or 4°C
Host Rabbit
Species Human
Alternative technique polyclonals
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