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anti-CXCR-7 Polyclonal Antibody

anti-CXCR-7 Polyclonal Antibody is available 1 time from Biovision labs

A1066-100 | anti-CXCR-7 Polyclonal Antibody size: CXCR-7 Polyclonal Antibody | 426.67 USD

Catalog number A1066-100
Supplier Biovision
Price 426.67 USD
Size CXCR-7 Polyclonal Antibody
1. Gene info
Identity 34284
Gene RNU6-7
Long gene name RNA, U6 small nuclear 7
Synonyms
  • U6-7
Locus 14q12
Discovery year 2008-06-10
Entrez gene record 101954275
Pubmed identfication
  • 12711679
RefSeq identity
  • NR_104084
Classification
  • Small nuclear RNAs
2. Gene info
Identity 23692
Gene ACKR3
Long gene name atypical chemokine receptor 3
Synonyms gene
  • CMKOR1
  • CXCR7
Synonyms gene name
  • chemokine orphan receptor 1
  • chemokine (C-X-C motif) receptor 7
Synonyms
  • RDC1
  • GPR159
GenBank acession
  • BC008459
Locus 2q37.3
Discovery year 2003-12-01
Entrez gene record 57007
Pubmed identfication
  • 16107333
  • 16148
RefSeq identity
  • NM_020311
Classification
  • Atypical chemokine receptors
Havana BLAST/BLAT OTTHUMG00000133295
Product images
    #CXCR#.jpg#0#.jpegAnti-CXCR-7 Antibody
Target of this antibody: ACKR3
Alternative names of antibody target: ACKR3; CXCR7; CMKOR1; GPR159; RDC1; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
Background information: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
Antibody host: Rabbit
Clonality of antibody: Polyclonal
Isotype: Rabbit IgG
This antibody reacts with: Human, Mouse, rat, Monkey
Immunogene sequence: Synthesized peptide derived from the C-terminal region of human CXCR-7 (290-370aa)
Concentration of antibody: 1 mg/ml
Form of antibody: Liquid
Formulation of this antibody: 100 µg (1mg/ml) of antibody containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
This antibody has been succesfully tested for use in following methods: WB, IHC, ELISA
Recommended usage: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000;
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Group Polyclonals and antibodies
About Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
French translation anticorps
Gene targetCXCR-7
Short name anti-CXCR-7 Polyclonal Antibody
Technique Polyclonal, Antibody, anti
Alternative name antibody to-CXCR-7 polyclonal (Antibody to)
Alternative technique polyclonals
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