INVS Polyclonal Antibody

• Catalog number
  CAC07612
• Price
  Please ask
• Size
  50 μg

• Other name
  Inversin,Inversion of embryo turning homolog,Nephrocystin-2,INVS,INV,NPHP2
• Immunogen
  Recombinant human Inversin protein (1-101AA)
• Verified reactivity
  Human
• Verified applications
  ELISA,WB,IHC,IF
• Raised in
  Rabbit
• Clonality
  Polyclonal
• Protein number
  Q9Y283
• Gene number
  Please refer to GenBank
• NCBI number
  Please refer to NCBI
• Purity
  Protein G purified, >95%
• Storage recommendation
  Aliquot and store at -20°C. Minimize freezing and thawing.
• Use before
  1 year
• Shipping requirements
  Blue ice
• Estimated production time
  3-7 business days
• Supplementary information
  Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
• Notes
  For research use only. Not for diagnostic procedures.
• Hyperlink
• Properties
  If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
• French translation
  anticorps

• Gene target
  INVS  
• Gene symbol
  INVS
• Short name
  INVS Polyclonal Antibody
• Technique
  Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Label
  Unconjugated
• Alternative name
  INVS polyclonal (antibody to-)
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:17870
• Gene
  INVS
• Long gene name
  inversin
• Synonyms gene
  • NPHP2
• Synonyms gene name
  • nephronophthisis 2 (infantile)
• Synonyms name
  • nephrocystin 2
• GenBank acession
  • AF039217
• Locus
  9q31.1
• Discovery year
  2002-06-11
• Entrez gene record
  27130
• Pubmed identfication
  • 12872123
• RefSeq identity
  • NM_014425
• Classification
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000020364

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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