GNE 477
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Catalog numberB1657-5
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PricePlease ask
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Size5 mg
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Alternative_nameGNE 477; GNE477; GNE 477; 5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine
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DescriptionGNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR.
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CAS Number1032754-81-6
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₁H₂₈N₈O₃S₂
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Molecular Weight504.63
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Cell PermeableYes
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Purity>98%
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineA potent and efficacious dual PI3K/mTOR inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD20527726
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PubChem CID25207689
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SMILESCC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)S(=O)(=O)C
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InChiInChI=1S/C21H28N8O3S2/c1-14-16(13-27-3-5-29(6-4-27)34(2,30)31)33-18-17(14)25-19(15-11-23-21(22)24-12-15)26-20(18)28-7-9-32-10-8-28/h11-12H,3-10,13H2,1-2H3,(H2,22,23,24)
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InChi KeyAKKCGLXULFRAET-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolGNE
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Short nameGNE 477
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Alternative nameglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 477
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Alternative to gene targetglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase, DMRV and GLCNE and IBM2 and NM and Uae1, GNE and IDBG-65042 and ENSG00000159921 and 10020, hydrolase activity, Cytoplasm, Gne and IDBG-143173 and ENSMUSG00000028479 and 50798, GNE and IDBG-633656 and ENSBTAG00000001142 and 782201
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Gene info
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Identity
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Gene
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Long gene nameglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
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Synonyms gene
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Synonyms gene name
- UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-11-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
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Locus Specific Databases