GNE 477

  • Catalog number
    B1657-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    GNE 477; GNE477; GNE 477; 5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine
  • Description
    GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR.
  • CAS Number
    1032754-81-6
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₁H₂₈N₈O₃S₂
  • Molecular Weight
    504.63
  • Cell Permeable
    Yes
  • Purity
    >98%
  • Solubilities
    DMSO
  • Handling
    Protect from air and light
  • Tag Line
    A potent and efficacious dual PI3K/mTOR inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • MDL Number
    MFCD20527726
  • PubChem CID
    25207689
  • SMILES
    CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)S(=O)(=O)C
  • InChi
    InChI=1S/C21H28N8O3S2/c1-14-16(13-27-3-5-29(6-4-27)34(2,30)31)33-18-17(14)25-19(15-11-23-21(22)24-12-15)26-20(18)28-7-9-32-10-8-28/h11-12H,3-10,13H2,1-2H3,(H2,22,23,24)
  • InChi Key
    AKKCGLXULFRAET-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
    GNE   477  
  • Gene symbol
    GNE
  • Short name
    GNE 477
  • Alternative name
    glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 477
  • Alternative to gene target
    glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase, DMRV and GLCNE and IBM2 and NM and Uae1, GNE and IDBG-65042 and ENSG00000159921 and 10020, hydrolase activity, Cytoplasm, Gne and IDBG-143173 and ENSMUSG00000028479 and 50798, GNE and IDBG-633656 and ENSBTAG00000001142 and 782201
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