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anti-TDG Antibody

anti-TDG Antibody is available 1 time from Biovision labs

6157-100 | anti-TDG Antibody size: TDG Antibody | 492.66 USD

Catalog number 6157-100
Supplier Biovision
Price 492.66 USD
Size TDG Antibody
1. Gene info
Identity 11700
Gene TDG
Long gene name thymine DNA glycosylase
Synonyms name
  • G/T mismatch-specific thymine DNA glycosylase
GenBank acession
  • U51166
Locus 12q23.3
Discovery year 1997-04-25
Entrez gene record 6996
Pubmed identfication
  • 8662714
  • 9299239
Classification
  • DNA glycosylases
Havana BLAST/BLAT OTTHUMG00000168418
Product images
    #0#.jpegTDG AntibodyTDG Antibody
Target of this antibody: TDG
Alternative names of antibody target: TDG.
Background information: In the DNA of higher eukaryotes, hydrolytic deamination of 5­methylcytosine to thymine leads to the formation of G/T mismatches. G/T mismatch specific Thymine DNA Glycosylase (TDG) is a nuclear protein which corrects G/T mismatches to G/C pairs by hydrolyzing the carbon nitrogen bond between the sugar phosphate backbone of the DNA and the mispaired thymine. TDG also corrects a subset of G/U mispairs inefficiently removed by the more abundant uracil glycosylases. Retinoic acid receptors interact physically and functionally with TDG, enhancing the ability of the retinoid X receptor and the retinoid X receptor/retinoid acid receptor complex to bind to their response elements. TDG interacts with, and is covalently modified by, the ubiquitin­like proteins SUMO­1 and SUMO­2/3, resulting in a reduction of the DNA substrate and AP site binding affinity of TDG. This sumoylation is associated with a significant increase in enzymatic turnover in reactions with a G/U substrate and the loss of G/T processing activity.
Antibody host: Rabbit
Clonality of antibody: Polyclonal
Isotype: Rabbit IgG
This antibody reacts with: Human, mouse, rat
Immunogene sequence: Fusion protein of human TDG
Concentration of antibody: 1 mg/ml
Form of antibody: Liquid
Formulation of this antibody: 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
Purification method: Affinity purified
This antibody has been succesfully tested for use in following methods: Western blot, Immunohistochemistry
Recommended usage: Western blot: 1:500 – 1:1000.
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetTDG
Short name anti-TDG Antibody
Technique Antibody, anti
Alternative name antibody to-TDG (Antibody to)
Alternative technique antibodies
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anti-TDG Antibody | Technique alternative | 01012193835
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