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KMT1E SETDB1 Antibody ALEXA FLUOR

KMT1E SETDB1 Antibody ALEXA FLUOR is available 5 times from Bioss primary conjugated antibodies. alexa fluor labs

bs-11670R-A350 | KMT1E/SETDB1 Antibody, ALEXA FLUOR 350 size: 100ul | 441.94 USD

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bs-11670R-A488 | KMT1E/SETDB1 Antibody, ALEXA FLUOR 488 size: 100ul | 441.94 USD

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bs-11670R-A555 | KMT1E/SETDB1 Antibody, ALEXA FLUOR 555 size: 100ul | 441.94 USD

Catalog number bs-11670R-A555
Price 441.94 USD
Size 100ul
Long name KMT1E/SETDB1 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
Also known as Anti-KMT1E/SETDB1 PAb ALEXA FLUOR 555
Conjugated with ALEXA FLUOR® 555
Excitation emission 553nm/568nm
Properties For facs or microscopy Alexa 1 conjugate.Very high photo stable ALEXA conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Conjugation Alexa Fluor,ALEXA FLUOR 555
French translation anticorps
Label ALEXA FLUOR 555
Alternative name KMT1E/SETDB1 Polyclonal Antibody, ALEXA FLUOR 555
1. Gene info
Identity 10761
Gene SETDB1
Long gene name SET domain bifurcated histone lysine methyltransferase 1
Synonyms gene name
  • SET domain, bifurcated 1
  • SET domain bifurcated 1
Synonyms
  • KG1T
  • KIAA0067
  • ESET
  • KMT1E
  • TDRD21
Synonyms name
  • tudor domain containing 21
GenBank acession
  • D31891
Locus 1q21.3
Discovery year 1999-07-19
Entrez gene record 9869
Pubmed identfication
  • 10343109
RefSeq identity
  • NM_001145415
Classification
  • Lysine methyltransferases
  • Tudor domain containing
  • SET domain containing
  • Methyl-CpG binding domain containing
Havana BLAST/BLAT OTTHUMG00000035003
Product images
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Product files

bs-11670R-A594 | KMT1E/SETDB1 Antibody, ALEXA FLUOR 594 size: 100ul | 441.94 USD

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bs-11670R-A647 | KMT1E/SETDB1 Antibody, ALEXA FLUOR 647 size: 100ul | 441.94 USD

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Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Target Antigen KMT1E/SETDB1
Specificity This is a highly specific antibody against KMT1E/SETDB1.
Modification Unmodified
Modification Site None
Clonality Polyclonal
Clone Polyclonal antibody
Concentration 1ug per 1ul
Immunogen range 210-260/1291
Subcellular location Nucleus
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SETDB1
Gene ID Number 9869
Swiss Prot Q15047
Tested applications IF(IHC-P)
Recommended dilutions IF(IHC-P)(1:50-200)
Crossreactivity Human, Mouse, Rat
Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the antigen Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).
Purification Purified by Protein A.
Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Synonyms ESET; KG1T; KMT1E; TDRD21; H3-K9-HMTase4; Histone-lysine N-methyltransferase SETDB1; ERG-associated protein with SET domain; Histone H3-K9 methyltransferase 4; H3-K9-HMTase 4; Lysine N-methyltransferase 1E; SET domain bifurcated 1; SETDB1; KIAA0067
Gene targetKMT1E/SETDB1
Short name Anti-KMT1E/SETDB1
Technique Antibody
Isotype Immunoglobulin G (IgG)
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Anti-KMT1E/SETDB1 | Technique alternative | 01011182697
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