Kallikrein, Human Plasma

Synonyms

Fletcher factor, Kininogenin, Plasma prekallikrein
Alternative_names

Fletcher factor, Kininogenin, Plasma prekallikrein
Description

A serine protease co-ordinating multiple physiological functions
Recombinant

No
Source

Human plasma
Purity by SDS PAGE

≥95%
Assay

SDS-PAGE
Activity Specifications test method

15 units/mg
Unit Definition

One unit is defined as the amount of enzyme that hydrolyzes one umol of D-Pro-Phe-Arg-pNA per minute at 25°C, pH 7.8.
Molecular Weight

86.0 – 88.0 kDa
Storage Temp

-70°C
Shipping

Dry ice
Shelf Life

12 months
Appearance

Liquid
Physical form description

Frozen in 20 mM Tris-HCl, pH 7.8, with 100 mM NaCl
Background Information

A serine protease that releases bradykinin from kininogen. Present in plasma as an inactive precursor prokallikrein.
Handling

Centrifuge the vial prior to opening.
Usage

For Research Use Only! Not to be used in humans
Datasheet
Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Identity

HGNC:6169
Gene

ITIH4
Long gene name

inter-alpha-trypsin inhibitor heavy chain 4
Synonyms gene
- ITIHL1
Synonyms gene name
- inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
- inter-alpha-trypsin inhibitor heavy chain family, member 4
Synonyms
- IHRP
- H4P
Synonyms name
- plasma Kallikrein-sensitive glycoprotein
GenBank acession
- D38535
Locus

3p21.1
Discovery year

1995-11-30
Entrez gene record

3700
Pubmed identfication
- 9480842
- 7805892
RefSeq identity
- NM_002218
Classification
- Inter-alpha-trypsin inhibitor heavy chains
VEGA ID

OTTHUMG00000159023