Alternative_name
2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide, AG 490
Description
Selectively inhibits EGF receptor auto-phosphorylation (IC₅₀ = 100 µM) and selectively inhibits DNA synthesis and cell growth; induces apoptosis. A JAK2 inhibitor. Blocks growth of leukemia cells in vivo and in vitro.
CAS Number
133550-30-8
Structure Available?
Yes
Salt Form
No
Molecular Formula
C₁₇H₁₄N₂O₃
Molecular Weight
294.31
Cell-Permeable?
Yes
Purity
≥99%
Solubilities
DMSO (100 mM) and ETOH (20 mM)
Handling
Protect from light and air
Tag Line
An EGFR inhibitor
Storage Condition
-20°C
Shipping Condition
gel pack
Shelf Life
24months
MDL Number
MFCD00236452
PubChem CID
5328779
SMILES
C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
InChi
InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChi Key
TUCIOBMMDDOEMM-RIYZIHGNSA-N
MSDS Available
Yes
Gene targetTyrphostin
490
Short name
Tyrphostin AG 490
Alternative name
Tyrphostin AG 490
