Tyrphostin AG 490

• Catalog number
  1570-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide, AG 490
• Description
  Selectively inhibits EGF receptor auto-phosphorylation (IC₅₀ = 100 µM) and selectively inhibits DNA synthesis and cell growth; induces apoptosis. A JAK2 inhibitor. Blocks growth of leukemia cells in vivo and in vitro.
• CAS Number
  133550-30-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₇H₁₄N₂O₃
• Molecular Weight
  294.31
• Cell Permeable
  Yes
• Purity
  ≥99%
• Solubilities
  DMSO (100 mM) and ETOH (20 mM)
• Handling
  Protect from light and air
• Tag Line
  An EGFR inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24months
• MDL Number
  MFCD00236452
• PubChem CID
  5328779
• PubChem CID Link
• SMILES
  C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
• InChi
  InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
• InChi Key
  TUCIOBMMDDOEMM-RIYZIHGNSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Tyrphostin   490  
• Short name
  Tyrphostin AG 490
• Alternative name
  Tyrphostin AG 490

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