Mouse anti Rb (Retinoblastoma)
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Catalog numberN140M
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PricePlease ask
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Size100 μg
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CategoryPrimary Antibodies
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Long descriptionThe immunogen for the anti-human retinoblastoma (Rb) was a recombinant protein corresponding to amino acids 393 to 572 of the human retinoblastoma sequence. Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes.
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Antibody come fromA recombinant protein corresponding to amino acids 387 to 982 of the human retinoblastoma sequence
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Other descriptionProvided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
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CloneXZ55
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Antigen antibody binding interactionMouse anti Rb (Retinoblastoma) Antibody
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Antibody is raised inMouse
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Antibody s reacts withHuman, Mouse, Rat, Chicken
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Antibody s reacts with these speciesThis antibody doesn't cross react with other species
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Antibody s specificityNo Data Available
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ApplicationWestern Blot, Immunoprecipitation
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Antibody s suited forApplications: Western Blot, Immunofluorescence
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Storage-20ºC
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Relevant references1) E.Harlow et. al. (1991) Mol. Cell Biol., 11: 5792-5799
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Protein numbersee ncbi
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WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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Gene target
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Gene symbolRB1, RBBP7, RBBP4
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Short nameMouse anti Rb (Retinoblastoma)
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TechniqueMouse, anti, antibody to, mouses
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Hostmouse
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IsotypeIgG1
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Labelunlabeled
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SpeciesMouse, Mouses
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Alternative nameMouse antibody to Rb (Retinoblastoma)
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Alternative techniquemurine, antibodies
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Gene info
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Identity
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Gene
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Long gene nameRB transcriptional corepressor 1
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Synonyms gene
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Synonyms gene name
- osteosarcoma
- retinoblastoma 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Receptor ligands
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameRB binding protein 7, chromatin remodeling factor
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Synonyms gene name
- retinoblastoma-binding protein 7
- retinoblastoma binding protein 7
- RB binding protein 7
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-01-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NURF complex
- EMSY complex
- SIN3 histone deacetylase complex subunits
- WD repeat domain containing
- NuRD complex subunits
- Polycomb repressive complex 2
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRB binding protein 4, chromatin remodeling factor
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Synonyms gene name
- retinoblastoma-binding protein 4
- retinoblastoma binding protein 4
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-05-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- EMSY complex
- SIN3 histone deacetylase complex subunits
- WD repeat domain containing
- NuRD complex subunits
- Polycomb repressive complex 2
- NURF complex
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data