Mouse anti Rb (Retinoblastoma)

• Catalog number
  N125M
• Price
  Please ask
• Size
  100 μg

• Category
  Primary Antibodies
• Long description
  The immunogen for the anti-human retinoblastoma (Rb) was a recombinant protein corresponding to amino acids 393 to 572 of the human retinoblastoma sequence. Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes.
• Antibody come from
  A recombinant protein corresponding to amino acids 387 to 982 of the human retinoblastoma sequence
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
• Clone
  XZ133
• Antigen antibody binding interaction
  Mouse anti Rb (Retinoblastoma) Antibody
• Antibody is raised in
  Mouse
• Antibody s reacts with
  Human, Mouse, Rat, Chicken
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Immunoprecipitation
• Antibody s suited for
  Applications: Immunoprecipitation
• Storage
  -20ºC
• Relevant references
  1) E.Harlow et. al. (1991) Mol. Cell Biol., 11: 5792-5799
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  Retinoblastoma  
• Gene symbol
  RB1, RBBP7, RBBP4
• Short name
  Mouse anti Rb (Retinoblastoma)
• Technique
  Mouse, anti, antibody to, mouses
• Host
  mouse
• Isotype
  IgG1
• Label
  unlabeled
• Species
  Mouse, Mouses
• Alternative name
  Mouse antibody to Rb (Retinoblastoma)
• Alternative technique
  murine, antibodies

Gene info

• Identity
  HGNC:9884
• Gene
  RB1
• Long gene name
  RB transcriptional corepressor 1
• Synonyms gene
  • OSRC
• Synonyms gene name
  • osteosarcoma
  • retinoblastoma 1
• Synonyms
  • RB
  • PPP1R130
• Synonyms name
  • prepro-retinoblastoma-associated protein
  • protein phosphatase 1, regulatory subunit 130
• GenBank acession
  • M15400
• Locus
  13q14.2
• Discovery year
  1986-01-01
• Entrez gene record
  5925
• Pubmed identfication
  • 1857421
  • 15057823
• RefSeq identity
  • NM_000321
• Classification
  • Receptor ligands
• VEGA ID
  OTTHUMG00000016900
• Locus Specific Databases
  • RB1-LSDB
  • LRG_517

Gene info

• Identity
  HGNC:9890
• Gene
  RBBP7
• Long gene name
  RB binding protein 7, chromatin remodeling factor
• Synonyms gene name
  • retinoblastoma-binding protein 7
  • retinoblastoma binding protein 7
  • RB binding protein 7
• Synonyms
  • RbAp46
• Synonyms name
  • G1/S transition control protein-binding protein RbAp46
  • retinoblastoma-binding protein 7
  • retinoblastoma-binding protein RbAp46
  • histone acetyltransferase type B subunit 2
  • retinoblastoma-binding protein p46
• GenBank acession
  • U35143
• Locus
  Xp22.2
• Discovery year
  1998-01-23
• Entrez gene record
  5931
• Pubmed identfication
  • 7503932
• RefSeq identity
  • NM_002893
• Classification
  • NURF complex
  • EMSY complex
  • SIN3 histone deacetylase complex subunits
  • WD repeat domain containing
  • NuRD complex subunits
  • Polycomb repressive complex 2
• VEGA ID
  OTTHUMG00000021198

Gene info

• Identity
  HGNC:9887
• Gene
  RBBP4
• Long gene name
  RB binding protein 4, chromatin remodeling factor
• Synonyms gene name
  • retinoblastoma-binding protein 4
  • retinoblastoma binding protein 4
• Synonyms
  • RbAp48
  • NURF55
  • lin-53
• GenBank acession
  • BC053904
• Locus
  1p35.1
• Discovery year
  1995-05-05
• Entrez gene record
  5928
• Pubmed identfication
  • 8350924
  • 14609955
  • 17531812
• RefSeq identity
  • NM_005610
• Classification
  • EMSY complex
  • SIN3 histone deacetylase complex subunits
  • WD repeat domain containing
  • NuRD complex subunits
  • Polycomb repressive complex 2
  • NURF complex
• VEGA ID
  OTTHUMG00000007998

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products