2-Deoxy-D-Glucose

Alternative_name

2-Deoxy-D-arabinohexose, 2-Deoxyglucose
Description

2-Deoxy-D-Glucose is a glucose analog that has long been known to act as a competitive inhibitor of glucose metabolism. Upon transport into the cells, 2-DG is phosphorylated by hexokinase to 2-DG-P. However, unlike G-6-P, 2-DG-P cannot be further metabolized by phosphohexose isomerase, which converts G-6-P to fructose-6-phosphate . 2-Deoxyglucose-P is trapped and accumulated in the cells, leading to inhibition of glycolysis mainly at the step of phosphorylation of glucose by hexokinase. Inhibition of this rate-limiting step by 2-DG causes a depletion of cellular ATP, leading to blockage of cell cycle progression and cell death in vitro.
CAS Number

154-17-6
Structure Available

Yes
Salt Form

No
Molecular Formula

C₆H₁₂O₅
Molecular Weight

164.16
Cell Permeable

Yes
Purity

≥98% GC
Solubilities

H2O (>15 mg/ml) or DMSO (>15 mg/ml)
Handling

Protect from air and moisture
Tag Line

A competitive inhibitor of glucose metabolism.
Storage Condition

+4°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD00151328
PubChem CID

439268
PubChem CID Link
SMILES

C1C(C(C(OC1O)CO)O)O
InChi

InChI=1S/C6H12O5/c7-2-4-6(10)3(8)1-5(9)11-4/h3-10H,1-2H2/t3-,4-,5?,6+/m1/s1
InChi Key

PMMURAAUARKVCB-CERMHHMHSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:17226
Gene

DGCR11
Long gene name

DiGeorge syndrome critical region gene 11
Synonyms gene name
- DiGeorge syndrome critical region gene 11
- DiGeorge syndrome critical region gene 11 (non-protein coding)
Synonyms
- DGS-D
GenBank acession
- L77561
Locus

22q11.21
Discovery year

2002-11-13
Entrez gene record

25786
Pubmed identfication
- 8776594
Classification
- Long non-coding RNAs with non-systematic symbols
VEGA ID

OTTHUMG00000186100

Identity

HGNC:13935
Gene

LY6G6D
Long gene name

lymphocyte antigen 6 family member G6D
Synonyms gene
- C6orf23
Synonyms gene name
- chromosome 6 open reading frame 23
- lymphocyte antigen 6 complex, locus G6D
Synonyms
- MEGT1
- Ly6-D
- G6D
- LY6-D
- NG25
Locus

6p21.33
Discovery year

2002-04-05
Entrez gene record

58530
Pubmed identfication
- 12079290
Classification
- LY6/PLAUR domain containing
VEGA ID

OTTHUMG00000137370

Identity

HGNC:15776
Gene

ULK4P2
Long gene name

ULK4 pseudogene 2
Synonyms gene
- FAM7A2
Synonyms gene name
- family with sequence similarity 7, member A2
- unc-51-like kinase 4 (C. elegans) pseudogene 2
Synonyms
- D-X
Locus

15q13.2
Discovery year

2001-06-29
Entrez gene record

100288380
Pubmed identfication
- 11829490
VEGA ID

OTTHUMG00000175653

Identity

HGNC:15775
Gene

ULK4P1
Long gene name

ULK4 pseudogene 1
Synonyms gene
- FAM7A1
Synonyms gene name
- family with sequence similarity 7, member A1
- family with sequence similarity 7, member A1 (non-protein coding)
- unc-51-like kinase 4 (C. elegans) pseudogene 1
Synonyms
- D-X
GenBank acession
- BC070492
Locus

15q13.3
Discovery year

2001-06-29
Entrez gene record

89838
Pubmed identfication
- 11829490
RefSeq identity
- XR_041690
VEGA ID

OTTHUMG00000162940

Identity

HGNC:3708
Gene

VEGFD
Long gene name

vascular endothelial growth factor D
Synonyms gene
- FIGF
Synonyms gene name
- c-fos induced growth factor (vascular endothelial growth factor D)
Synonyms
- VEGF-D
GenBank acession
- AJ000185
Locus

Xp22.2
Discovery year

1997-03-27
Entrez gene record

2277
Pubmed identfication
- 9479493
RefSeq identity
- NM_004469
Classification
- VEGF family
VEGA ID

OTTHUMG00000021175
Locus Specific Databases
- Global Variome shared LOVD