PDGFR beta, Active

Synonyms

PDGR. platelet-derived growth factor receptor, beta polypeptide
Alternative_names

PDGR. platelet-derived growth factor receptor, beta polypeptide
Description

Important factors regulating cell proliferation, cellular differentiation, cell growth and development
Recombinant

Yes
Source

Baculovirus (Sf9 insect cells)
Purity by SDS PAGE

≥90%
Assay

SDS-PAGE
Activity Specifications test method

The specific activity of PDGFRb was determined to be 20 nmol /min/mg as per activity assay protocol.
Molecular Weight

96.0 kDa
Storage Temp

-80°C
Shipping

dry ice
Shelf Life

12 months
Concentration

0.1mg/ml
Appearance

Liquid
Physical form description

Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Background Information

PDGFRb (platelet-derived growth factor receptor b) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. PDGFRb deficient mice are hemorrhagic, severely anemic and exhibit a defect in kidney glomeruli function (1). However, absence of PDGFRb has no impact on major blood vessels and the heart. PDGFRb expression and activity is elevated in several cancers and inhibition of PDGFRb activity blocks progression of renal carcinoma in an animal model (2).
Handling

Centrifuge the vial prior to opening.
Usage

For Research Use Only! Not to be used in humans
Datasheet

Identity

HGNC:8804
Gene

PDGFRB
Long gene name

platelet derived growth factor receptor beta
Synonyms gene
- PDGFR
Synonyms gene name
- platelet-derived growth factor receptor, beta polypeptide
Synonyms
- JTK12
- CD140b
- PDGFR1
GenBank acession
- M21616
Locus

5q32
Discovery year

2001-06-22
Entrez gene record

5159
RefSeq identity
- NM_002609
Classification
- Receptor tyrosine kinases
- CD molecules
- I-set domain containing
VEGA ID

OTTHUMG00000130053