Chaetocin, Methyltransferase inhibitor

  • Catalog number
    SIH-351-200UG
  • Price
    Please ask
  • Size
    200 µg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    28097-03-2
  • Description
    Methyltransferase inhibitor
  • Molecular weight
    696,9 g/mol
  • Primary research fields
    Cell Signaling, Epigenetics, Cancer
  • Other name
    2,​2',​3S,​3'S,​5aR,​5'aR,​6,​6'-​octahydro-​3,​3'-​bis(hydroxymethyl)-​2,​2'-​dimethyl-​[10bR,​10'bR(11aS,​11'aS)-​bi-​3,​11a-​epidithio-​11aH-​pyrazino[1',​2':1,​5]pyrrolo[2,​3-​b]indole]-​1,​1',​4,​4'-​tetrone
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C30H28N6O6S4
  • Origin
    Synthetic
  • Purity pourcentage
    >99% (TLC), NMR conforms
  • Soluble in
    Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol
  • Physical appearance
    Lyophilized Solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Harmful- Harmful by inhalation, in contact with skin, and if swallowed. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Precautionary Statements: P280 Wear protective gloves/protective clothing/eye protection/face protection. P301+P312- IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P304+P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. Hazard Statements: H302- Harmful if swallowed H312- Harmful in contact with skin H332- Harmful if inhaled
  • PubChem number
    161591
  • Scientific context
    Inhibits the lysine methyltransferase SU (VAR)3-9. Displays antimyeloma activity in IL-6-dependent myeloma cell lines. Cell permeable.
  • Bibliography
    1. Greiner D., et al. (2005) Nat Chem Biol. 1: 143. 2. Isham, C.R., et al. (2007) Blood. 109: 2579.
  • Release date
    28-Aug-2012
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of Chaetocin (SIH-351), a Lys methyltransferase inhibitor. CAS #: 28097-03-2 . Molecular Formula: C30H28N6O6S4. Molecular Weight: 696.9 g/mol. Chemical structure of Chaetocin, a Lys methyltransferase inhibitor (SIH-351). CAS # 28097-03-2 . Molecular Formula: C30H28N6O6S4.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.0002
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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