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Stock availabilitIn Stock
In Stock
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CAS number
28097-03-2
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Description
Methyltransferase inhibitor
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Molecular weight
696,9 g/mol
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Primary research fields
Cell Signaling, Epigenetics, Cancer
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Other name
2,2',3S,3'S,5aR,5'aR,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10bR,10'bR(11aS,11'aS)-bi-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C30H28N6O6S4
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Origin
Synthetic
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Purity pourcentage
>99% (TLC), NMR conforms
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Soluble in
Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol
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Physical appearance
Lyophilized Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Harmful- Harmful by inhalation, in contact with skin, and if swallowed. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Precautionary Statements: P280 Wear protective gloves/protective clothing/eye protection/face protection. P301+P312- IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P304+P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. Hazard Statements: H302- Harmful if swallowed H312- Harmful in contact with skin H332- Harmful if inhaled
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PubChem number
161591
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Scientific context
Inhibits the lysine methyltransferase SU (VAR)3-9. Displays antimyeloma activity in IL-6-dependent myeloma cell lines. Cell permeable.
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Bibliography
1. Greiner D., et al. (2005) Nat Chem Biol. 1: 143. 2. Isham, C.R., et al. (2007) Blood. 109: 2579.
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Release date
28-Aug-2012
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Chaetocin (SIH-351), a Lys methyltransferase inhibitor. CAS #: 28097-03-2 . Molecular Formula: C30H28N6O6S4. Molecular Weight: 696.9 g/mol. Chemical structure of Chaetocin, a Lys methyltransferase inhibitor (SIH-351). CAS # 28097-03-2 . Molecular Formula: C30H28N6O6S4.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.0002
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.