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Sunitinib Malate Sutent

Sunitinib Malate Sutent is available 3 times from Biovision labs

1611-25 | Sunitinib Malate (Sutent) size: 25 mg | 144.81 USD

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1611-1000 | Sunitinib Malate (Sutent) size: 1 g | 588.98 USD

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1611-100 | Sunitinib Malate (Sutent) size: 100 mg | 245.81 USD

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Alternative_name Sunitinib Maleate, SU-11248, Sutent, PHA-290940AD, PNU-290940AD
Description Sunitinib is a potent inhibitor of CSF-1 receptor kinase in an enzyme assay, with an IC₅₀ of 7 nM, and inhibits receptor phosphorylation in a cellular assay with an IC₅₀ of 61 nM. Sunitinib inhibits SCF-induced phosphotyrosine levels on KIT (IC₅₀ = 1 - 10 nM) and reduced SCF-stimulated ERK1/2 phosphorylation with an IC₅₀ value consistent with that for inhibition of KIT phosphotyrosine levels. Sunitinib also inhibited SCF-stimulated proliferation in NCI-H526 cells (IC₅₀ = 2 nM).
CAS Number 341031-54-7
Structure Available? Yes
Salt Form No
Molecular Formula C₂₂H₂₇FN₄O₂.C₄H₆O₅
Molecular Weight 532.56
Cell-Permeable? Yes
Purity ≥99% by HPLC
Solubilities DMSO (40 mg/ml)
Handling Protect from air and moisture
Tag Line A CSF-1 receptor kinase inhibitor
Storage Condition -20°C
Shipping Condition RT
Shelf Life 24months
MDL Number MFCD08282795
PubChem CID 6456015
SMILES CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(= O)O
InChi InChI=1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14 (20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8, 11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8, 9)/b17-12-;/t;2-/m.0/s1
InChi Key LBWFXVZLPYTWQI-IPOVEDGCSA-N
MSDS Available Yes
Gene targetSunitinib Malate Sutent
Short name Sunitinib Malate (Sutent)
Alternative name Sunitinib Malate (Sutent)
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