LARGE Antibody / Like acetylglucosaminyltransferase

• Catalog number
  F53896-0.05ML
• Price
  Please ask
• Size
  0.05 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  LARGE / Like acetylglucosaminyltransferase
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 1:1000-2000
• Intented use
  This LARGE antibodyis to be used only for research purposes and not for diagnostics..
• Gene ID
  9215
• Uniprot
  O95461
• Purity
  Antigen affinity
• Description
  Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). Phosphorylated O- mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide.
• Immunogen
  A portion of amino acids 365-398 from the human protein was used as the immunogen for the LARGE antibody.
• Storage
  Aliquot the LARGE antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Like   acetylglucosaminyltransferase  
• Gene symbol
  LARGE1, B3GNTL1, EXTL1
• Short name
  Anti- LARGE / Like acetylglucosaminyltransferase
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to LARGE / Like acetylglucosaminyltransferase
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6511
• Gene
  LARGE1
• Long gene name
  LARGE xylosyl- and glucuronyltransferase 1
• Synonyms gene
  • LARGE
• Synonyms gene name
  • like-glycosyltransferase
• Synonyms
  • KIAA0609
• Synonyms name
  • like-acetylglucosaminyltransferase
• GenBank acession
  • AJ007583
• Locus
  22q12.3
• Discovery year
  1999-06-02
• Entrez gene record
  9215
• Pubmed identfication
  • 9892679
  • 12966029
  • 22223806
• RefSeq identity
  • NM_133642
• Classification
  • MicroRNA protein coding host genes
  • Glycosyltransferase family 8
• VEGA ID
  OTTHUMG00000150914
• Locus Specific Databases
  • Leiden Muscular Dystrophy pages
  • LRG_856

Gene info

• Identity
  HGNC:21727
• Gene
  B3GNTL1
• Long gene name
  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1
• Synonyms
  • B3GNT8
• GenBank acession
  • AY634364
• Locus
  17q25.3
• Discovery year
  2003-07-17
• Entrez gene record
  146712
• RefSeq identity
  • NM_001009905
• Classification
  • Glycosyltransferase family 2
• VEGA ID
  OTTHUMG00000177788

Gene info

• Identity
  HGNC:3515
• Gene
  EXTL1
• Long gene name
  exostosin like glycosyltransferase 1
• Synonyms gene name
  • exostoses (multiple)-like 1
• Synonyms
  • EXTL
  • MGC70794
• Synonyms name
  • glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase
  • alpha-N-acetylglucosaminyltransferase II
  • glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N- acetylglucosaminyltransferase
  • exostosin-L
• GenBank acession
  • U67191
• Locus
  1p36.11
• Discovery year
  1997-06-12
• Entrez gene record
  2134
• Pubmed identfication
  • 9037597
• RefSeq identity
  • NM_004455
• Classification
  • Exostosin glycosyltransferase family
• VEGA ID
  OTTHUMG00000007509

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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