Caspase-8 Substrate IETD-pNA

  • Catalog number
    1063-1000
  • Price
    Please ask
  • Size
    1000 assays
  • Alternative_name
    Ac-IETD-pNA, Caspase-8 Substrate, Colorimetric
  • Description
    Ready-to-use colorimetric substrate for FLICE/caspase-8 and related caspases that recognize the amino acid sequence IETD. The sequence IETD is based on caspase-8 cleavage site in CPP32/Caspase-3 proenzyme. FLICE and related caspase activity can be quantified by spectrophotometric detection of free pNA (l= 400 nm) after cleavage from the peptide substrate IETD-pNA, using a spectrophotometer or multi-well plate reader.
  • Structure Available
    No
  • Peptide sequence
    Ac-Ile-Glu-Thr-Asp-pNA
  • Salt Form
    No
  • Molecular Formula
    C₂₇H₃₈N₆O₁₂
  • Molecular Weight
    638.6
  • Cell Permeable
    No
  • Purity
    >95% by HPLC
  • Handling
    Protect from light and moisture
  • Tag Line
    A Caspase-8 substrate
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    12 months
  • MDL Number
    MFCD01318840
  • PubChem CID
    25108782
  • SMILES
    CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C
  • InChi
    InChI=1S/C27H38N6O12/c1-5-13(2)22(28-15(4)35)26(42)30-18(10-11-20(36)37)24(40)32-23(14(3)34)27(43)31-19(12-21(38)39)25(41)29-16-6-8-17(9-7-16)33(44)45/h6-9,13-14,18-19,22-23,34H,5,10-12H2,1-4H3,(H,28,35)(H,29,41)(H,30,42)(H,31,43)(H,32,40)(H,36,37)(H,38,39)/t13-,14+,18-,19-,22-,23-/m0/s1
  • InChi Key
    FHURKTIGZAIQGR-BQCLNCLCSA-N
  • MSDS Available
    Yes
  • Additional description
    Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
MeSH Data
  • Name
  • Concept
    Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
  • Tree numbers
    • E05.599.495
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