AGI-5198

• Catalog number
  2369-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  N-​[2-​(cyclohexylamino)-​1-​(2-​methylphenyl)-​2-​oxoethyl]-​N-​(3-​fluorophenyl)-​2-​methyl-​1H-​imidazole-​1-​acetamide; IDH-C35
• Description
  A potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1). AGI-5198 inhibits IDH1 R132H and R132C mutants in vitro with IC₅₀ values of 0.07 and 0.16 µM, respectively, but not wild-type IDH1, wild-type IDH2, or IDH2 mutants (IC₅₀ s > 100 μM). Under conditions of near complete 2-HG (2-hydroxyglutarate) inhibition, AGI-5198 can induce demethylation of histone H3K9me3 and expression
• CAS Number
  1355326-35-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₇H₃₁FN₄O₂
• Molecular Weight
  462.56
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~25 mg/ml) or Ethanol (~ 15 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  A potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1)
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  56645356
• PubChem CID Link
• SMILES
  CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C
• InChi
  InChI=1S/C27H31FN4O2/c1-19-9-6-7-14-24(19)26(27(34)30-22-11-4-3-5-12-22)32(23-13-8-10-21(28)17-23)25(33)18-31-16-15-29-20(31)2/h6-10,13-17,22,26H,3-5,11-12,18H2,1-2H3,(H,30,34)
• InChi Key
  FNYGWXSATBUBER-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  AGI-5198  
• Short name
  AGI-5198
• Alternative name
  AGI-5198

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