NFkB p105/P50 Antibody
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Catalog numberPB9149
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PricePlease ask
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Size0,1 mg
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Target antigenNFkB p105/P50
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ClonalityPolyclonal antibody
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ClonePolyclonal antibody
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Raised inrabbit
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Type of the antibodyIgG polyclonal antibody
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Product formfreeze-dried
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Reacts with speciesrat
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AnalysesWB,IHC-P
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ImmunogenE.coli-derived human NFkB p105/P50 recombinant protein (Position: M1-Q360). Human NFkB p105/P50 shares 93% amino acid (aa) sequence identity with mouse NFkB p105/P50.
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Product configurationEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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PurificationImmunogen affinity purified.
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SolubilizationThe powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtionsKeep the NFkB p105/P50 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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TipsThe NFkB p105/P50 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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BackgroundNuclear factor NF-kappa-B p105 subunit, also called EBP-1 is a protein that in humans is encoded by the NFKB1 gene. By fluorescence in situ hybridization, the gene was assigned to human chromosome 4q24. NFKB1 is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NFKB1 proteins by p105 and generation of p50 by a cotranslational processing.
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Related articles1. Adler, A. S., Sinha, S., Kawahara, T. L. A., Zhang, J. Y., Segal, E., Chang, H. Y. Motif module map reveals enforcement of aging by continual NF-kappa-beta activity. Genes Dev. 21: 3244-3257, 2007. 2. Baek, S. H., Ohgi, K. A., Rose, D. W., Koo, E. H., Glass, C. K., Rosenfeld, M. G. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappa-B and beta-amyloid precursor protein. Cell 110: 55-67, 2002. 3. Huxford, T., Huang, D.-B., Malex, S., Ghosh, G. The crystal structure of the I-kappa-B-alpha complex reveals mechanisms of NF-kappa-B inactivation. Cell 95: 759-770, 1998.
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Gene NameNFKB1
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Protein NameNuclear factor NF-kappa-B p105 subunit
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Gene Full Namenuclear factor of kappa light polypeptide gene enhancer in B-cells 1
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SynonymsDKFZp686C01211 antibody|DNA binding factor KBF1 antibody|DNA binding factor KBF1 EBP1 antibody|DNA-binding factor KBF1 antibody|EBP 1 antibody|EBP-1 antibody|EBP1 antibody|KBF1 antibody|MGC54151 antibody|NF kappa B antibody|NF kappaB antibody|NF kappabeta antibody|NF kB1 antibody|NFkappaB antibody|NFKB 1 antibody|NFKB p105 antibody|NFKB p50 antibody|NFKB1 antibody|NFKB1_HUMAN antibody|Nuclear factor kappa B DNA binding subunit antibody|Nuclear factor kappa-B, subunit 1 antibody|Nuclear factor NF kappa B p105 subunit antibody|Nuclear factor NF kappa B p50 subunit antibody|Nuclear factor NF-kappa-B p50 subunit antibody|Nuclear factor of kappa light polypeptide gene enhancer in B cells 1 antibody|Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 antibody|p105 antibody|p50 antibody|p84/NF-kappa-B1 p98 antibody
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Uniprot IDP19838
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Entrez GeneID4790
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PropertiesIf you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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GeneNF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory
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French translationanticorps
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Gene target
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Gene symbolH3P40, CD40, NFKB1, ASCC1, ARHGEF7
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Short nameNFkB p105/P50 Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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Alternative nameNFkB p105/P50 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameH3 histone pseudogene 40
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Synonyms
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Locus
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Discovery year2019-08-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
Gene info
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Identity
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Gene
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Long gene nameCD40 molecule
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor receptor superfamily, member 5
- CD40 molecule, TNF receptor superfamily member 5
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-08-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- Tumor necrosis factor receptor superfamily
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namenuclear factor kappa B subunit 1
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Synonyms gene name
- nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-11-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NF-kappa B complex subunits
- Ankyrin repeat domain containing
- IPT domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameactivating signal cointegrator 1 complex subunit 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2004-03-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Activating signal cointegrator 1 complex
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRho guanine nucleotide exchange factor 7
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Synonyms gene name
- Rho guanine nucleotide exchange factor (GEF) 7
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-11-21
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Pleckstrin homology domain containing
- Dbl family Rho GEFs
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data