BAY 87-2243-d8

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Cas number

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Chemical s molecular weight

533.57
Chemical s main applications

Isotope labelled BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation. It is found to inhibit HIF-1α and HIF-2α protein accumulation under hypoxic conditions in non-small cell lung cancer cell line H460. It inhibits mitochondrial complex I activity and therefore may be used in antitumor treatment to overcome chemo- and radiotherapy- resistance of hypoxic tumors.
Other name

1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]-piperazine-d8
Chemical s formula

C26H18D8F3N7O2
Physical properties

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Melting temperature

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Boiling temperature

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Chemical s soluble in

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Stability conditions

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Storage

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Chemical s specifications

Identity

HGNC:24284
Gene

TRAPPC12
Long gene name

trafficking protein particle complex subunit 12
Synonyms gene
- TTC15
Synonyms gene name
- tetratricopeptide repeat domain 15
- trafficking protein particle complex 12
Synonyms
- CGI-87
- TTC-15
GenBank acession
- BC017475
Locus

2p25.3
Discovery year

2003-12-22
Entrez gene record

51112
Pubmed identfication
RefSeq identity
- NM_016030
Classification
- Trafficking protein particle complex subunits
- Tetratricopeptide repeat domain containing
VEGA ID

OTTHUMG00000090328