BAY-1217389

  • Catalog number
    B1295-25
  • Price
    Please ask
  • Size
    25 mg
  • Alternative_name
    N-Cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide
  • Description
    BAY-1217389 is a potent, and selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity. Upon administration, BAY-1217389 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC), accelerates mitosis, causes chromosomal misalignment and mitotic checkpoint complex destabilization.
  • CAS Number
    1554458-53-5
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₇H₂₄F₅N₅O₃
  • Molecular Weight
    561.51
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO
  • Handling
    Protect from air and light
  • Tag Line
    A potent, and selective serine/threonine kinase monopolar spindle 1 (Mps1, TTK) inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • PubChem CID
    78320750
  • SMILES
    CC1=C(C=CC(=C1)C2=CN=C3N2N=C(C=C3NCCC(F)(F)F)OC4=C(C(=C(C=C4)OC)F)F)C(=O)NC5CC5
  • InChi
    InChI=1S/C27H24F5N5O3/c1-14-11-15(3-6-17(14)26(38)35-16-4-5-16)19-13-34-25-18(33-10-9-27(30,31)32)12-22(36-37(19)25)40-21-8-7-20(39-2)23(28)24(21)29/h3,6-8,11-13,16,33H,4-5,9-10H2,1-2H3,(H,35,38)
  • InChi Key
    WNEILUNVMHVMPH-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    BAY-1217389
  • Alternative name
    BAY-1217389
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