SIRT6 Antibody

  • Catalog number
    6692-30T
  • Price
    Please ask
  • Size
    30 μg
  • Antibody Target
    SIRT6
  • Target Alternative Name
    SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6
  • Antibody Type
    Polyclonal
  • Species Reactivities
    Human, Mouse
  • Immunogen Sequence
    Recombinant Human Sirtuin 6 (Cat # 7699)
  • Accession
    Q8N6T7
  • Gene Id
    51548
  • Appearance
    Colorless liquid
  • Form
    Liquid
  • Concentration
    0.5 mg/ml
  • Formulation
    30 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
  • Purification
    Affinity Purified Antibody
  • Application
    Western blot
  • Positive Control
    Western Blot: Jurkat cell lysate, mouse muscle lysate, Rat kidney lysate, Recombinant proteins
  • Application And Usages
    Western blot: 1-4 µg
  • Description
    Human Sirtuins function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56 of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-α.
  • Storage Condition
    -20 °C
  • Shipping Condition
    gel pack
  • Shelf Life
    12 months
  • Usage
    For Research Use Only! Not to be used in humans.
  • Handling
    The antibody solution should be gently mixed before use.
  • Western Blot Verified
    Verified
  • Immunocytochemistry Verified
    Not Verified
  • Immunofluorescence Verified
    Not Verified
  • Immunoprecipitation Verified
    Not Verified
  • ELISA Verified
    Not Verified
  • ChIP Verified
    Not Verified
  • Dot Blot Verified
    Not Verified
  • Flow Cytometry Verified
    Not Verified
  • Properties
    If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
    SIRT6  
  • Gene symbol
    SIRT6
  • Short name
    SIRT6 Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Isotype
    Rabbit IgG
  • Alternative name
    SIRT6 (antibody to-)
  • Alternative technique
    antibodies
Gene info
  • Identity
  • Gene
  • Long gene name
    sirtuin 6
  • Synonyms gene name
    • sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6
    • sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
  • GenBank acession
  • Locus
  • Discovery year
    2001-03-20
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Sirtuins
  • VEGA ID
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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