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P505 15 hydrochloride

P505 15 hydrochloride is available 4 times from Biovision labs

9583-5 | P505-15 hydrochloride size: 5 mg | 361.56 USD

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9583-25 | P505-15 hydrochloride size: 25 mg | 855.11 USD

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9583-5 | P505-15 hydrochloride for cell activation size: 5 mg | 262.85 USD

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9583-25 | P505-15 hydrochloride for cell activation size: 25 mg | 800.02 USD

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Alternate Name/Synonyms 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide hydrochloride; PRT062607; PRT2607; BIIB-057
Appearance White solid
Formulation N/A
CAS Number 1370261-97-4
Peptide sequence N/A
Molecular Formula C₁₉H₂₃N₉O. HCl
Molecular Weight 429.91
Purity ≥98% by HPLC
Solubility/Reconstitution Instructions DMSO (>25 mg/ml)
Handling Protect from air and light
Tagline A potent, cell-permeable, highly selective, small molecule SYK inhibitor
Storage Temp. -20°C
Shipping Conditions gel pack
Shelf Life 36 months
MDL Number N/A
PubChem CID 56948527
Category Biochemicals
Description P505-15 is a potent, cell-permeable, highly selective, small molecule SYK inhibitor (IC₅₀ = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases. P505-15 blocks B cell receptor-mediated cell signaling and activation in whole blood (IC₅₀s = 0.27 and 0.28 µM, respectively), as well as Fcɛ receptor 1-mediated basophil degranulation (IC₅₀ = 0.15 µM).
CAS number 1370261-97-4
Molecular weight 429.91
Other name 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide hydrochloride; PRT062607; PRT2607; BIIB-057
Molecular formula C₁₉H₂₃N₉O. HCl
Physical appearance White solid
Supplied with N/A
Is this a salt? No
Is it cell-permeable? Yes
Purification ≥98% by HPLC
Reconstitute instructions DMSO (>25 mg/ml)
Storage condition -20°C
Shipping condition gel pack
Maximum time for storage 36 months
Storage instructions Protect from air and light
Technique activation
Tissue cell
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