POLH Antibody

• Catalog number
  PB9813
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  POLH
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  mouse
• Analyses
  WB
• Immunogen
  E.coli-derived human POLH recombinant protein (Position: A157-R361). Human POLH shares 93.6% amino acid (aa) sequence identity with mouse POLH.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the POLH Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The POLH Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  DNA polymerase eta (Pol η), is a protein that in humans is encoded by the POLH gene. This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
• Related articles
  1. "Entrez Gene: POLH polymerase (DNA directed), eta". 2. Johnson RE, Kondratick CM, Prakash S, Prakash L (July 1999). "hRAD30 mutations in the variant form of xeroderma pigmentosum". Science 285 (5425): 263–5. 3. Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F (June 1999). "The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta". Nature 399 (6737): 700–4.
• Gene Name
  POLH
• Protein Name
  DNA polymerase eta
• Gene Full Name
  polymerase (DNA directed), eta
• Synonyms
  DNA polymerase eta antibody|FLJ16395 antibody|FLJ21978 antibody|Polh antibody|POLH_HUMAN antibody|polymerase DNA directed eta antibody|RAD30 antibody|RAD30 homolog A antibody|RAD30A antibody|Xeroderma pigmentosum variant type protein antibody|XP V antibody|XPV antibody
• Uniprot ID
  Q9Y253
• Entrez GeneID
  5429
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  POLH  
• Gene symbol
  POLQ, POLH-AS1, POLH
• Short name
  POLH Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  POLH (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9186
• Gene
  POLQ
• Long gene name
  DNA polymerase theta
• Synonyms gene name
  • polymerase (DNA directed), theta
  • polymerase (DNA) theta
• Synonyms
  • POLH
• GenBank acession
  • AF052573
• Locus
  3q13.33
• Discovery year
  1999-04-15
• Entrez gene record
  10721
• Pubmed identfication
  • 10395804
• RefSeq identity
  • NM_199420
• Classification
  • DNA polymerases
• VEGA ID
  OTTHUMG00000159396

Gene info

• Identity
  HGNC:40459
• Gene
  POLH-AS1
• Long gene name
  POLH antisense RNA 1
• Synonyms
  • RP3-337H4.8
• Locus
  6p21.1
• Discovery year
  2017-08-30
• Pubmed identfication
  • 28839111
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:9181
• Gene
  POLH
• Long gene name
  DNA polymerase eta
• Synonyms gene name
  • polymerase (DNA directed), eta
  • polymerase (DNA) eta
• Synonyms
  • RAD30A
  • XP-V
• GenBank acession
  • AB024313
• Locus
  6p21.1
• Discovery year
  1997-09-12
• Entrez gene record
  5429
• Pubmed identfication
  • 20012583
  • 10385124
  • 10398605
• RefSeq identity
  • NM_006502
• Classification
  • DNA polymerases
  • Xeroderma pigmentosum complementation groups
• VEGA ID
  OTTHUMG00000014743
• Locus Specific Databases
  • LRG_470

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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