Mitofusin 2 Antibody, ALEXA FLUOR 350

• Catalog number
  bs-2988R-A350
• Price
  Please ask
• Size
  100ul

• Long name
  Mitofusin 2 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
• Also known as
  Anti-Mitofusin 2 PAb ALEXA FLUOR 350
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 350
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Mitofusin 2
• Specificity
  This is a highly specific antibody against Mitofusin 2.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  1-50/757
• Subcellular location
  Cytoplasm
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Mitofusin 2
• Gene ID Number
  9927
• Swiss Prot
  O95140
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  343nm/442nm
• Synonyms
  HSG; MARF; CMT2A; CPRP1; CMT2A2; Mitofusin-2; Transmembrane GTPase MFN2; MFN2; KIAA0214
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 350
• French translation
  anticorps

• Gene target
  Mitofusin  
• Gene symbol
  MFN2
• Short name
  Anti-Mitofusin 2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 350
• Alternative name
  Mitofusin 2 Polyclonal Antibody, ALEXA FLUOR 350
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:16877
• Gene
  MFN2
• Long gene name
  mitofusin 2
• Synonyms
  • CPRP1
  • KIAA0214
  • MARF
  • CMT2A2
• GenBank acession
  • AF036536
• Locus
  1p36.22
• Discovery year
  2003-02-25
• Entrez gene record
  9927
• Pubmed identfication
  • 12499352
  • 11181170
• RefSeq identity
  • NM_014874
• VEGA ID
  OTTHUMG00000002392
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • LRG_255

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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