UBE2O Polyclonal Antibody

• Catalog number
  CAC07332
• Price
  Please ask
• Size
  50 μg

• Other name
  (E3-independent) E2 ubiquitin-conjugating enzyme (EC:2.3.2.242 Publications,UBE2O,KIAA1734,E2/E3 hybrid ubiquitin-protein ligase UBE2O,Ubiquitin carrier protein O,Ubiquitin-conjugating enzyme E2 O,Ubiquitin-conjugating enzyme E2 of 230 kDa,Ubiquitin-conjugating enzyme E2-230K,Ubiquitin-protein ligase O
• Immunogen
  Recombinant human (E3-independent) E2 ubiquitin-conjugating enzyme protein (10-277AA)
• Verified reactivity
  Human
• Verified applications
  ELISA,WB. Recommended dilution:WB:1:500-2000
• Raised in
  Rabbit
• Clonality
  Polyclonal
• Protein number
  Q9C0C9
• Gene number
  Please refer to GenBank
• NCBI number
  Please refer to NCBI
• Purity
  Caprylic Acid Ammonium Sulfate Precipitation Purified
• Storage recommendation
  Aliquot and store at -20°C. Minimize freezing and thawing.
• Use before
  1 year
• Shipping requirements
  Blue ice
• Estimated production time
  3-7 business days
• Supplementary information
  E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853).
• Notes
  For research use only. Not for diagnostic procedures.
• Hyperlink
• Properties
  If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
• French translation
  anticorps

• Gene target
  UBE2O  
• Gene symbol
  UBE2O
• Short name
  UBE2O Polyclonal Antibody
• Technique
  Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Label
  Unconjugated
• Alternative name
  UBE2O polyclonal (antibody to-)
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:29554
• Gene
  UBE2O
• Long gene name
  ubiquitin conjugating enzyme E2 O
• Synonyms gene name
  • ubiquitin-conjugating enzyme E2O
• Synonyms
  • E2-230K
• GenBank acession
  • AB051521
• Locus
  17q25.1
• Discovery year
  2005-12-15
• Entrez gene record
  63893
• Pubmed identfication
  • 11311559
  • 11214970
• RefSeq identity
  • NM_022066
• VEGA ID
  OTTHUMG00000180178

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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